In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium

Abstract Ca-based porous and rough bioceramic surfaces were coated onto zirconium by micro-arc oxidation (MAO). Subsequently, the MAO-coated zirconium surfaces were covered with an antimicrobial chitosan layer via the dip coating method to develop an antimicrobial, bioactive, and biocompatible compo...

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Autores principales:	Salim Levent Aktug, Salih Durdu, Selin Kalkan, Kultigin Cavusoglu, Metin Usta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40be1669221c4165bc92a18aa2a226a6
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spelling	oai:doaj.org-article:40be1669221c4165bc92a18aa2a226a62021-12-02T16:17:17ZIn vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium10.1038/s41598-021-94502-z2045-2322https://doaj.org/article/40be1669221c4165bc92a18aa2a226a62021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94502-zhttps://doaj.org/toc/2045-2322Abstract Ca-based porous and rough bioceramic surfaces were coated onto zirconium by micro-arc oxidation (MAO). Subsequently, the MAO-coated zirconium surfaces were covered with an antimicrobial chitosan layer via the dip coating method to develop an antimicrobial, bioactive, and biocompatible composite biopolymer and bioceramic layer for implant applications. Cubic ZrO2, metastable Ca0.15Zr0.85O1.85, and Ca3(PO4)2 were detected on the MAO surface by powder-XRD. The existence of chitosan on the MAO-coated Zr surfaces was verified by FTIR. The micropores and thermal cracks on the bioceramic MAO surface were sealed using a chitosan coating, where the MAO surface was porous and rough. All elements such as Zr, O, Ca, P, and C were homogenously distributed across both surfaces. Moreover, both surfaces indicated hydrophobic properties. However, the contact angle of the MAO surface was lower than that of the chitosan-based MAO surface. In vitro bioactivity on both surfaces was investigated via XRD, SEM, and EDX analyses post-immersion in simulated body fluid (SBF) for 14 days. In vitro bioactivity was significantly enhanced on the chitosan-based MAO surface with respect to the MAO surface. In vitro microbial adhesions on the chitosan-based MAO surfaces were lower than the MAO surfaces for Staphylococcus aureus and Escherichia coli.Salim Levent AktugSalih DurduSelin KalkanKultigin CavusogluMetin UstaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salim Levent Aktug Salih Durdu Selin Kalkan Kultigin Cavusoglu Metin Usta In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
description	Abstract Ca-based porous and rough bioceramic surfaces were coated onto zirconium by micro-arc oxidation (MAO). Subsequently, the MAO-coated zirconium surfaces were covered with an antimicrobial chitosan layer via the dip coating method to develop an antimicrobial, bioactive, and biocompatible composite biopolymer and bioceramic layer for implant applications. Cubic ZrO2, metastable Ca0.15Zr0.85O1.85, and Ca3(PO4)2 were detected on the MAO surface by powder-XRD. The existence of chitosan on the MAO-coated Zr surfaces was verified by FTIR. The micropores and thermal cracks on the bioceramic MAO surface were sealed using a chitosan coating, where the MAO surface was porous and rough. All elements such as Zr, O, Ca, P, and C were homogenously distributed across both surfaces. Moreover, both surfaces indicated hydrophobic properties. However, the contact angle of the MAO surface was lower than that of the chitosan-based MAO surface. In vitro bioactivity on both surfaces was investigated via XRD, SEM, and EDX analyses post-immersion in simulated body fluid (SBF) for 14 days. In vitro bioactivity was significantly enhanced on the chitosan-based MAO surface with respect to the MAO surface. In vitro microbial adhesions on the chitosan-based MAO surfaces were lower than the MAO surfaces for Staphylococcus aureus and Escherichia coli.
format	article
author	Salim Levent Aktug Salih Durdu Selin Kalkan Kultigin Cavusoglu Metin Usta
author_facet	Salim Levent Aktug Salih Durdu Selin Kalkan Kultigin Cavusoglu Metin Usta
author_sort	Salim Levent Aktug
title	In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
title_short	In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
title_full	In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
title_fullStr	In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
title_full_unstemmed	In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
title_sort	in vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40be1669221c4165bc92a18aa2a226a6
work_keys_str_mv	AT salimleventaktug invitrobiologicalandantimicrobialpropertiesofchitosanbasedbioceramiccoatingsonzirconium AT salihdurdu invitrobiologicalandantimicrobialpropertiesofchitosanbasedbioceramiccoatingsonzirconium AT selinkalkan invitrobiologicalandantimicrobialpropertiesofchitosanbasedbioceramiccoatingsonzirconium AT kultigincavusoglu invitrobiologicalandantimicrobialpropertiesofchitosanbasedbioceramiccoatingsonzirconium AT metinusta invitrobiologicalandantimicrobialpropertiesofchitosanbasedbioceramiccoatingsonzirconium
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In vitro biological and antimicrobial properties of chitosan-based bioceramic coatings on zirconium

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