Adipose MDM2 regulates systemic insulin sensitivity
Abstract The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53...
Guardado en:
Autores principales: | Philip Hallenborg, Benjamin Anderschou Holbech Jensen, Even Fjære, Rasmus Koefoed Petersen, Mohammed-Samir Belmaâti, Sarah Søndergård Rasmussen, Jon Petur Gunnarsson, Pernille Lauritzen, Kenneth King Yip Cheng, Martin Hermansson, Si Brask Sonne, Christer S. Ejsing, Aimin Xu, Irina Kratchmarova, Marcus Krüger, Lise Madsen, Karsten Kristiansen, Blagoy Blagoev |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/40be2ce071a64faf8d38428ae1f155cb |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells
por: Xiaomu Li, et al.
Publicado: (2016) -
Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum
por: Sihui Wang, et al.
Publicado: (2018) -
Tumorogénesis y proteína mdm2
por: Flores P,Carlos, et al.
Publicado: (2000) -
MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
por: Moscetti I, et al.
Publicado: (2016) -
Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
por: Helge M. Magnussen, et al.
Publicado: (2020)