Adipose MDM2 regulates systemic insulin sensitivity

Adipose MDM2 regulates systemic insulin sensitivity

Abstract The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53...

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Main Authors: Philip Hallenborg, Benjamin Anderschou Holbech Jensen, Even Fjære, Rasmus Koefoed Petersen, Mohammed-Samir Belmaâti, Sarah Søndergård Rasmussen, Jon Petur Gunnarsson, Pernille Lauritzen, Kenneth King Yip Cheng, Martin Hermansson, Si Brask Sonne, Christer S. Ejsing, Aimin Xu, Irina Kratchmarova, Marcus Krüger, Lise Madsen, Karsten Kristiansen, Blagoy Blagoev
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/40be2ce071a64faf8d38428ae1f155cb
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