Transcriptomic profile of cationic channels in human pulmonary arterial hypertension

Abstract The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregu...

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Autores principales:	Francisco Perez-Vizcaino, Angel Cogolludo, Gema Mondejar-Parreño
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40c07f33681c45b986b8384fe5b327e7
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spelling	oai:doaj.org-article:40c07f33681c45b986b8384fe5b327e72021-12-02T14:53:42ZTranscriptomic profile of cationic channels in human pulmonary arterial hypertension10.1038/s41598-021-95196-z2045-2322https://doaj.org/article/40c07f33681c45b986b8384fe5b327e72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95196-zhttps://doaj.org/toc/2045-2322Abstract The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and KV1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K+ channels including the downregulation of KV1.1, KV1.4, KV1.6, KV7.1, KV7.4, KV9.3 and TWIK2 and the upregulation of KCa1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, CaV1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na+ and TRP channels remains to be investigated.Francisco Perez-VizcainoAngel CogolludoGema Mondejar-ParreñoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francisco Perez-Vizcaino Angel Cogolludo Gema Mondejar-Parreño Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
description	Abstract The dysregulation of K+ channels is a hallmark of pulmonary arterial hypertension (PAH). Herein, the channelome was analyzed in lungs of patients with PAH in a public transcriptomic database. Sixty six (46%) mRNA encoding cationic channels were dysregulated in PAH with most of them downregulated (83%). The principal component analysis indicated that dysregulated cationic channel expression is a signature of the disease. Changes were very similar in idiopathic, connective tissue disease and congenital heart disease associated PAH. This analysis 1) is in agreement with the widely recognized pathophysiological role of TASK1 and KV1.5, 2) supports previous preliminary reports pointing to the dysregulation of several K+ channels including the downregulation of KV1.1, KV1.4, KV1.6, KV7.1, KV7.4, KV9.3 and TWIK2 and the upregulation of KCa1.1 and 3) points to other cationic channels dysregulated such as Kv7.3, TALK2, CaV1 and TRPV4 which might play a pathophysiological role in PAH. The significance of other changes found in Na+ and TRP channels remains to be investigated.
format	article
author	Francisco Perez-Vizcaino Angel Cogolludo Gema Mondejar-Parreño
author_facet	Francisco Perez-Vizcaino Angel Cogolludo Gema Mondejar-Parreño
author_sort	Francisco Perez-Vizcaino
title	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
title_short	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
title_full	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
title_fullStr	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
title_full_unstemmed	Transcriptomic profile of cationic channels in human pulmonary arterial hypertension
title_sort	transcriptomic profile of cationic channels in human pulmonary arterial hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40c07f33681c45b986b8384fe5b327e7
work_keys_str_mv	AT franciscoperezvizcaino transcriptomicprofileofcationicchannelsinhumanpulmonaryarterialhypertension AT angelcogolludo transcriptomicprofileofcationicchannelsinhumanpulmonaryarterialhypertension AT gemamondejarparreno transcriptomicprofileofcationicchannelsinhumanpulmonaryarterialhypertension
_version_	1718389378864119808

Transcriptomic profile of cationic channels in human pulmonary arterial hypertension

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