NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in neutrophils contributes to systemic inflammation....

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Autores principales:	Randilea D. Nichols, Jakob von Moltke, Russell E. Vance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40c0e00ed4a847b7b597037368e2c3e2
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spelling	oai:doaj.org-article:40c0e00ed4a847b7b597037368e2c3e22021-12-02T15:38:54ZNAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease10.1038/s41467-017-02266-w2041-1723https://doaj.org/article/40c0e00ed4a847b7b597037368e2c3e22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02266-whttps://doaj.org/toc/2041-1723Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in neutrophils contributes to systemic inflammation.Randilea D. NicholsJakob von MoltkeRussell E. VanceNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Randilea D. Nichols Jakob von Moltke Russell E. Vance NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
description	Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in neutrophils contributes to systemic inflammation.
format	article
author	Randilea D. Nichols Jakob von Moltke Russell E. Vance
author_facet	Randilea D. Nichols Jakob von Moltke Russell E. Vance
author_sort	Randilea D. Nichols
title	NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
title_short	NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
title_full	NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
title_fullStr	NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
title_full_unstemmed	NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
title_sort	naip/nlrc4 inflammasome activation in mrp8+ cells is sufficient to cause systemic inflammatory disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40c0e00ed4a847b7b597037368e2c3e2
work_keys_str_mv	AT randileadnichols naipnlrc4inflammasomeactivationinmrp8cellsissufficienttocausesystemicinflammatorydisease AT jakobvonmoltke naipnlrc4inflammasomeactivationinmrp8cellsissufficienttocausesystemicinflammatorydisease AT russellevance naipnlrc4inflammasomeactivationinmrp8cellsissufficienttocausesystemicinflammatorydisease
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NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease

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