Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they...

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Autores principales:	Claudio Isella, Francesco Brundu, Sara E. Bellomo, Francesco Galimi, Eugenia Zanella, Roberta Porporato, Consalvo Petti, Alessandro Fiori, Francesca Orzan, Rebecca Senetta, Carla Boccaccio, Elisa Ficarra, Luigi Marchionni, Livio Trusolino, Enzo Medico, Andrea Bertotti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40c353ad1ecb4e42b22ea92e35a88433
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spelling	oai:doaj.org-article:40c353ad1ecb4e42b22ea92e35a884332021-12-02T17:06:19ZSelective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer10.1038/ncomms151072041-1723https://doaj.org/article/40c353ad1ecb4e42b22ea92e35a884332017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15107https://doaj.org/toc/2041-1723Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they define CRC intrinsic subtypes (CRIS) and evaluate their prognostic and predictive potential.Claudio IsellaFrancesco BrunduSara E. BellomoFrancesco GalimiEugenia ZanellaRoberta PorporatoConsalvo PettiAlessandro FioriFrancesca OrzanRebecca SenettaCarla BoccaccioElisa FicarraLuigi MarchionniLivio TrusolinoEnzo MedicoAndrea BertottiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudio Isella Francesco Brundu Sara E. Bellomo Francesco Galimi Eugenia Zanella Roberta Porporato Consalvo Petti Alessandro Fiori Francesca Orzan Rebecca Senetta Carla Boccaccio Elisa Ficarra Luigi Marchionni Livio Trusolino Enzo Medico Andrea Bertotti Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
description	Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they define CRC intrinsic subtypes (CRIS) and evaluate their prognostic and predictive potential.
format	article
author	Claudio Isella Francesco Brundu Sara E. Bellomo Francesco Galimi Eugenia Zanella Roberta Porporato Consalvo Petti Alessandro Fiori Francesca Orzan Rebecca Senetta Carla Boccaccio Elisa Ficarra Luigi Marchionni Livio Trusolino Enzo Medico Andrea Bertotti
author_facet	Claudio Isella Francesco Brundu Sara E. Bellomo Francesco Galimi Eugenia Zanella Roberta Porporato Consalvo Petti Alessandro Fiori Francesca Orzan Rebecca Senetta Carla Boccaccio Elisa Ficarra Luigi Marchionni Livio Trusolino Enzo Medico Andrea Bertotti
author_sort	Claudio Isella
title	Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
title_short	Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
title_full	Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
title_fullStr	Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
title_full_unstemmed	Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
title_sort	selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40c353ad1ecb4e42b22ea92e35a88433
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Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

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