Paradoxical impact of two folate receptors, FRα and RFC, in ovarian cancer: effect on cell proliferation, invasion and clinical outcome.

Despite being an essential vitamin, folate has been implicated to enhance tumor growth, as evidenced by reports on overexpression of folate receptor alpha (FRα) in carcinomas. The role of another folate transporter, reduced folate carrier (RFC), is largely unknown. This study investigated the roles...

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Auteurs principaux: Michelle K Y Siu, Daniel S H Kong, Hoi Yan Chan, Esther S Y Wong, Philip P C Ip, LiLi Jiang, Hextan Y S Ngan, Xiao-Feng Le, Annie N Y Cheung
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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Accès en ligne:https://doaj.org/article/40c416e45d574a99bedf8a7ff451949c
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