Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes

Sureewan Duangjit,1,2 Boonnada Pamornpathomkul,1 Praneet Opanasopit,1 Theerasak Rojanarata,1 Yasuko Obata,2 Kozo Takayama,2 Tanasait Ngawhirunpat11Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand; 2Department of Pharmaceutics, Hoshi University, Shinagawa-ku, Tokyo, JapanAbstract:...

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Autores principales:	Duangjit S, Pamornpathomkul B, Opanasopit P, Rojanarata T, Obata Y, Takayama K, Ngawhirunpat T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/40c558b101f54dc694fe5b61171d3f61
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spelling	oai:doaj.org-article:40c558b101f54dc694fe5b61171d3f612021-12-02T01:46:42ZRole of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes1178-2013https://doaj.org/article/40c558b101f54dc694fe5b61171d3f612014-04-01T00:00:00Zhttp://www.dovepress.com/role-of-the-charge-carbon-chain-length-and-content-of-surfactant-on-th-a16663https://doaj.org/toc/1178-2013 Sureewan Duangjit,1,2 Boonnada Pamornpathomkul,1 Praneet Opanasopit,1 Theerasak Rojanarata,1 Yasuko Obata,2 Kozo Takayama,2 Tanasait Ngawhirunpat11Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand; 2Department of Pharmaceutics, Hoshi University, Shinagawa-ku, Tokyo, JapanAbstract: The objective of this study was to investigate the influence of surfactant charge, surfactant carbon chain length, and surfactant content on the physicochemical characteristics (ie, vesicle size, zeta potential, elasticity, and entrapment efficiency), morphology, stability, and in vitro skin permeability of meloxicam (MX)-loaded liposome. Moreover, the mechanism for the liposome-enhanced skin permeation of MX was determined by Fourier transform infrared spectroscopy and differential scanning calorimetry. The model formulation used in this study was obtained using a response surface method incorporating multivariate spline interpolation (RSM-S). Liposome formulations with varying surfactant charge (anionic, neutral, and cationic), surfactant carbon chain length (C4, C12, and C16), and surfactant content (10%, 20%, and 29%) were prepared. The formulation comprising 29% cationic surfactant with a C16 chain length was found to be the optimal liposome for the transdermal delivery of MX. The skin permeation flux of the optimal formulation was 2.69-fold higher than that of a conventional liposome formulation. Our study revealed that surfactants affected the physicochemical characteristics, stability, and skin permeability of MX-loaded liposomes. These findings provide important fundamental information for the development of liposomes as transdermal drug delivery systems.Keywords: optimal liposome, optimization, transdermal drug delivery, surfactant charge, surfactant carbon chain length, surfactant contentDuangjit SPamornpathomkul BOpanasopit PRojanarata TObata YTakayama KNgawhirunpat TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2005-2017 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Duangjit S Pamornpathomkul B Opanasopit P Rojanarata T Obata Y Takayama K Ngawhirunpat T Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
description	Sureewan Duangjit,1,2 Boonnada Pamornpathomkul,1 Praneet Opanasopit,1 Theerasak Rojanarata,1 Yasuko Obata,2 Kozo Takayama,2 Tanasait Ngawhirunpat11Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand; 2Department of Pharmaceutics, Hoshi University, Shinagawa-ku, Tokyo, JapanAbstract: The objective of this study was to investigate the influence of surfactant charge, surfactant carbon chain length, and surfactant content on the physicochemical characteristics (ie, vesicle size, zeta potential, elasticity, and entrapment efficiency), morphology, stability, and in vitro skin permeability of meloxicam (MX)-loaded liposome. Moreover, the mechanism for the liposome-enhanced skin permeation of MX was determined by Fourier transform infrared spectroscopy and differential scanning calorimetry. The model formulation used in this study was obtained using a response surface method incorporating multivariate spline interpolation (RSM-S). Liposome formulations with varying surfactant charge (anionic, neutral, and cationic), surfactant carbon chain length (C4, C12, and C16), and surfactant content (10%, 20%, and 29%) were prepared. The formulation comprising 29% cationic surfactant with a C16 chain length was found to be the optimal liposome for the transdermal delivery of MX. The skin permeation flux of the optimal formulation was 2.69-fold higher than that of a conventional liposome formulation. Our study revealed that surfactants affected the physicochemical characteristics, stability, and skin permeability of MX-loaded liposomes. These findings provide important fundamental information for the development of liposomes as transdermal drug delivery systems.Keywords: optimal liposome, optimization, transdermal drug delivery, surfactant charge, surfactant carbon chain length, surfactant content
format	article
author	Duangjit S Pamornpathomkul B Opanasopit P Rojanarata T Obata Y Takayama K Ngawhirunpat T
author_facet	Duangjit S Pamornpathomkul B Opanasopit P Rojanarata T Obata Y Takayama K Ngawhirunpat T
author_sort	Duangjit S
title	Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
title_short	Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
title_full	Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
title_fullStr	Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
title_full_unstemmed	Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
title_sort	role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/40c558b101f54dc694fe5b61171d3f61
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_version_	1718402890100375552

Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes

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