Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters

Objectives: We aimed to investigate the prevalence of restless legs syndrome (RLS) and sleep disorders in patients with rheumatoid arthritis (RA), and the association of iron deficiency with them. Materials and methods: The study included 72 patients with RA (59 females, 13 males), and 50 healthy co...

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Autores principales:	Salih Demir, Adem Kucuk, Mustafa Altas, Erkan Cure
Formato:	article
Lenguaje:	EN
Publicado:	Karolinum Press 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/40c6f7fb8c844fd1969b9e19822eee21
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spelling	oai:doaj.org-article:40c6f7fb8c844fd1969b9e19822eee212021-11-22T09:31:01ZRestless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters1805-96941211-428610.14712/18059694.2021.24https://doaj.org/article/40c6f7fb8c844fd1969b9e19822eee212021-11-01T00:00:00Zhttps://actamedica.lfhk.cuni.cz/64/3/0137/https://doaj.org/toc/1211-4286https://doaj.org/toc/1805-9694Objectives: We aimed to investigate the prevalence of restless legs syndrome (RLS) and sleep disorders in patients with rheumatoid arthritis (RA), and the association of iron deficiency with them. Materials and methods: The study included 72 patients with RA (59 females, 13 males), and 50 healthy control subjects (57 females, 15 males). Assessments were made using the International RLS Rating Scale, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Fatigue Severity Scale (FSS), Beck anxiety and depression index and the SF-36 quality of life scores. Results: We found that the frequency of RLS in RA patients was 29.1% and 13.8% in healthy control (p = 0.021). RA patients had 44.4% iron deficiency and 5.5% anemia of chronic disease. We found that 52.3% of patients with iron deficiency had RLS. There was an independent relationship between present of RLS and FSS (Beta [β] = 0.317, p = 0.005) and total iron binding capacity (TIBC) (β = 0.244, p = 0.031). There was an independent relationship between RLS severity score and PSQI (β = 0.264, p = 0.025) and social functionality (β = 0.302, p = 0.009). Conclusion: The prevalence of iron deficiency is high in RA in the developing countries. Analysis obtained in patients with RA is suggestive of an association between iron deficiency and increased frequency of RLS. The presence of RLS in patients with RA negatively affects sleep quality, psychiatric status, and quality of life of patients with RA. TIBC value may be a predictive marker for early detection of RLS in patients with RA.Salih DemirAdem KucukMustafa AltasErkan CureKarolinum PressarticleMedicineRENActa Medica, Vol 64, Iss 3, Pp 137-144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Salih Demir Adem Kucuk Mustafa Altas Erkan Cure Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
description	Objectives: We aimed to investigate the prevalence of restless legs syndrome (RLS) and sleep disorders in patients with rheumatoid arthritis (RA), and the association of iron deficiency with them. Materials and methods: The study included 72 patients with RA (59 females, 13 males), and 50 healthy control subjects (57 females, 15 males). Assessments were made using the International RLS Rating Scale, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Fatigue Severity Scale (FSS), Beck anxiety and depression index and the SF-36 quality of life scores. Results: We found that the frequency of RLS in RA patients was 29.1% and 13.8% in healthy control (p = 0.021). RA patients had 44.4% iron deficiency and 5.5% anemia of chronic disease. We found that 52.3% of patients with iron deficiency had RLS. There was an independent relationship between present of RLS and FSS (Beta [β] = 0.317, p = 0.005) and total iron binding capacity (TIBC) (β = 0.244, p = 0.031). There was an independent relationship between RLS severity score and PSQI (β = 0.264, p = 0.025) and social functionality (β = 0.302, p = 0.009). Conclusion: The prevalence of iron deficiency is high in RA in the developing countries. Analysis obtained in patients with RA is suggestive of an association between iron deficiency and increased frequency of RLS. The presence of RLS in patients with RA negatively affects sleep quality, psychiatric status, and quality of life of patients with RA. TIBC value may be a predictive marker for early detection of RLS in patients with RA.
format	article
author	Salih Demir Adem Kucuk Mustafa Altas Erkan Cure
author_facet	Salih Demir Adem Kucuk Mustafa Altas Erkan Cure
author_sort	Salih Demir
title	Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
title_short	Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
title_full	Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
title_fullStr	Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
title_full_unstemmed	Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters
title_sort	restless leg syndrome and sleep disorders in patients with rheumatoid arthritis and its relation with anemia parameters
publisher	Karolinum Press
publishDate	2021
url	https://doaj.org/article/40c6f7fb8c844fd1969b9e19822eee21
work_keys_str_mv	AT salihdemir restlesslegsyndromeandsleepdisordersinpatientswithrheumatoidarthritisanditsrelationwithanemiaparameters AT ademkucuk restlesslegsyndromeandsleepdisordersinpatientswithrheumatoidarthritisanditsrelationwithanemiaparameters AT mustafaaltas restlesslegsyndromeandsleepdisordersinpatientswithrheumatoidarthritisanditsrelationwithanemiaparameters AT erkancure restlesslegsyndromeandsleepdisordersinpatientswithrheumatoidarthritisanditsrelationwithanemiaparameters
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Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters

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