Orthogonal control of mean and variability of endogenous genes in a human cell line

Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.

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Autores principales:	Alain R. Bonny, João Pedro Fonseca, Jesslyn E. Park, Hana El-Samad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40c72744eec947a8be9ff201dea8efdf
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spelling	oai:doaj.org-article:40c72744eec947a8be9ff201dea8efdf2021-12-02T15:22:40ZOrthogonal control of mean and variability of endogenous genes in a human cell line10.1038/s41467-020-20467-82041-1723https://doaj.org/article/40c72744eec947a8be9ff201dea8efdf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20467-8https://doaj.org/toc/2041-1723Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.Alain R. BonnyJoão Pedro FonsecaJesslyn E. ParkHana El-SamadNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad Orthogonal control of mean and variability of endogenous genes in a human cell line
description	Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expression.
format	article
author	Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad
author_facet	Alain R. Bonny João Pedro Fonseca Jesslyn E. Park Hana El-Samad
author_sort	Alain R. Bonny
title	Orthogonal control of mean and variability of endogenous genes in a human cell line
title_short	Orthogonal control of mean and variability of endogenous genes in a human cell line
title_full	Orthogonal control of mean and variability of endogenous genes in a human cell line
title_fullStr	Orthogonal control of mean and variability of endogenous genes in a human cell line
title_full_unstemmed	Orthogonal control of mean and variability of endogenous genes in a human cell line
title_sort	orthogonal control of mean and variability of endogenous genes in a human cell line
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40c72744eec947a8be9ff201dea8efdf
work_keys_str_mv	AT alainrbonny orthogonalcontrolofmeanandvariabilityofendogenousgenesinahumancellline AT joaopedrofonseca orthogonalcontrolofmeanandvariabilityofendogenousgenesinahumancellline AT jesslynepark orthogonalcontrolofmeanandvariabilityofendogenousgenesinahumancellline AT hanaelsamad orthogonalcontrolofmeanandvariabilityofendogenousgenesinahumancellline
_version_	1718387379255902208

Orthogonal control of mean and variability of endogenous genes in a human cell line

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