Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients

ObjectiveEctodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diag...

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Autores principales:	Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ectodysplasin A T2DM insulin resistance hepatokine hyperlipidemia Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/40c936ad9bbf4e89b4a354df154647c1
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spelling	oai:doaj.org-article:40c936ad9bbf4e89b4a354df154647c12021-11-09T05:35:28ZIncreased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients1664-239210.3389/fendo.2021.737624https://doaj.org/article/40c936ad9bbf4e89b4a354df154647c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.737624/fullhttps://doaj.org/toc/1664-2392ObjectiveEctodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes.MethodsA total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured.ResultsSerum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, p < 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β (p < 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level (p < 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM (p < 0.05).ConclusionsSerum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.Xia DengZhensheng CaiYanyan LiXunan WuLi ZhaoHaoxiang LiKe ChenPanpan ZhangChenxi WangZhicong ZhaoLing YangGuoyue YuanFrontiers Media S.A.articleectodysplasin AT2DMinsulin resistancehepatokinehyperlipidemiaDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ectodysplasin A T2DM insulin resistance hepatokine hyperlipidemia Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	ectodysplasin A T2DM insulin resistance hepatokine hyperlipidemia Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xia Deng Zhensheng Cai Yanyan Li Xunan Wu Li Zhao Haoxiang Li Ke Chen Panpan Zhang Chenxi Wang Zhicong Zhao Ling Yang Guoyue Yuan Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
description	ObjectiveEctodysplasin A (EDA), a newly discovered hepatokine, has recently been considered to be closely related to glycolipid metabolism disorders, but the pathophysiological effects of EDA are still poorly understood. This study was the first time to determine the level of serum EDA in newly diagnosed type 2 diabetes mellitus (T2DM) patients, and to explore the relationships between serum EDA levels and various metabolic indexes.MethodsA total of 184 subjects were enrolled in the study, including 92 subjects with newly diagnosed T2DM and 92 subjects with age- and sex-matched normal glucose tolerance (NGT). Serum EDA levels were determined using enzyme-linked immunosorbent assay (ELISA). Oral glucose tolerance test, glycosylated hemoglobin c (HbA1c), and insulin were also measured.ResultsSerum EDA levels were significantly increased in the T2DM group than in the NGT group (359.91 ± 117.99 vs. 265.82 ± 86.51 pg/ml, p < 0.001). Serum EDA levels were positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), fasting plasma glucose (FPG), HbA1c, 2-hour postprandial plasma glucose (2hPG), fasting plasma insulin (FIns), fasting C peptide (FCP), triglyceride (TG), HOMA-IR, and negatively correlated with high-density lipoprotein cholesterol (HDL-c) and HOMA-β (p < 0.05). Multiple stepwise regression analysis demonstrated that 2hPG and FIns were independent influencing factors of serum EDA level (p < 0.05). Logistic regression analysis showed that serum EDA level was significantly independently correlated with T2DM (p < 0.05).ConclusionsSerum EDA levels are significantly higher in T2DM patients, suggesting that EDA may play a role in the occurrence and development of T2DM.
format	article
author	Xia Deng Zhensheng Cai Yanyan Li Xunan Wu Li Zhao Haoxiang Li Ke Chen Panpan Zhang Chenxi Wang Zhicong Zhao Ling Yang Guoyue Yuan
author_facet	Xia Deng Zhensheng Cai Yanyan Li Xunan Wu Li Zhao Haoxiang Li Ke Chen Panpan Zhang Chenxi Wang Zhicong Zhao Ling Yang Guoyue Yuan
author_sort	Xia Deng
title	Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
title_short	Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
title_full	Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
title_fullStr	Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
title_full_unstemmed	Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients
title_sort	increased circulating levels of ectodysplasin a in newly diagnosed type 2 diabetic patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/40c936ad9bbf4e89b4a354df154647c1
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Increased Circulating Levels of Ectodysplasin A in Newly Diagnosed Type 2 Diabetic Patients

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