Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

Abstract Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-...

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Autores principales:	Anping Guo, Jin Lu, Haizhu Tan, Zejian Kuang, Ying Luo, Tian Yang, Junlan Xu, Jishuang Yu, Canhong Wen, Aizong Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40c9f3b1e2e740849a605f15a2e0a59e
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spelling	oai:doaj.org-article:40c9f3b1e2e740849a605f15a2e0a59e2021-12-02T13:27:08ZRisk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study10.1038/s41598-021-86853-42045-2322https://doaj.org/article/40c9f3b1e2e740849a605f15a2e0a59e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86853-4https://doaj.org/toc/2045-2322Abstract Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-confirmed COVID-19 infection in Hefei, China and being discharged between January 20 2020 and March 16 2020. Demographic information, clinical treatment, and laboratory data for the participants were extracted from medical records. A prolonged LOS was defined as equal to or greater than the median length of hospitable stay. The median LOS for the 75 patients was 17 days (IQR 13–22). We used univariable and multivariable logistic regressions to explore the risk factors associated with a prolonged hospital LOS. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated. The median age of the 75 patients was 47 years. Approximately 75% of the patients had mild or general disease. The univariate logistic regression model showed that female sex and having a fever on admission were significantly associated with longer duration of hospitalization. The multivariate logistic regression model enhances these associations. Odds of a prolonged LOS were associated with male sex (aOR 0.19, 95% CI 0.05–0.63, p = 0.01), having fever on admission (aOR 8.27, 95% CI 1.47–72.16, p = 0.028) and pre-existing chronic kidney or liver disease (aOR 13.73 95% CI 1.95–145.4, p = 0.015) as well as each 1-unit increase in creatinine level (aOR 0.94, 95% CI 0.9–0.98, p = 0.007). We also found that a prolonged LOS was associated with increased creatinine levels in patients with chronic kidney or liver disease (p < 0.001). In conclusion, female sex, fever, chronic kidney or liver disease before admission and increasing creatinine levels were associated with prolonged LOS in patients with COVID-19.Anping GuoJin LuHaizhu TanZejian KuangYing LuoTian YangJunlan XuJishuang YuCanhong WenAizong ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anping Guo Jin Lu Haizhu Tan Zejian Kuang Ying Luo Tian Yang Junlan Xu Jishuang Yu Canhong Wen Aizong Shen Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
description	Abstract Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission associated with hospital length of stay (LOS) and provide a risk assessment for clinical treatment. To address this, we conduct a retrospective study, which involved patients with laboratory-confirmed COVID-19 infection in Hefei, China and being discharged between January 20 2020 and March 16 2020. Demographic information, clinical treatment, and laboratory data for the participants were extracted from medical records. A prolonged LOS was defined as equal to or greater than the median length of hospitable stay. The median LOS for the 75 patients was 17 days (IQR 13–22). We used univariable and multivariable logistic regressions to explore the risk factors associated with a prolonged hospital LOS. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated. The median age of the 75 patients was 47 years. Approximately 75% of the patients had mild or general disease. The univariate logistic regression model showed that female sex and having a fever on admission were significantly associated with longer duration of hospitalization. The multivariate logistic regression model enhances these associations. Odds of a prolonged LOS were associated with male sex (aOR 0.19, 95% CI 0.05–0.63, p = 0.01), having fever on admission (aOR 8.27, 95% CI 1.47–72.16, p = 0.028) and pre-existing chronic kidney or liver disease (aOR 13.73 95% CI 1.95–145.4, p = 0.015) as well as each 1-unit increase in creatinine level (aOR 0.94, 95% CI 0.9–0.98, p = 0.007). We also found that a prolonged LOS was associated with increased creatinine levels in patients with chronic kidney or liver disease (p < 0.001). In conclusion, female sex, fever, chronic kidney or liver disease before admission and increasing creatinine levels were associated with prolonged LOS in patients with COVID-19.
format	article
author	Anping Guo Jin Lu Haizhu Tan Zejian Kuang Ying Luo Tian Yang Junlan Xu Jishuang Yu Canhong Wen Aizong Shen
author_facet	Anping Guo Jin Lu Haizhu Tan Zejian Kuang Ying Luo Tian Yang Junlan Xu Jishuang Yu Canhong Wen Aizong Shen
author_sort	Anping Guo
title	Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
title_short	Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
title_full	Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
title_fullStr	Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
title_full_unstemmed	Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study
title_sort	risk factors on admission associated with hospital length of stay in patients with covid-19: a retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40c9f3b1e2e740849a605f15a2e0a59e
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Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

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