Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.

Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. W...

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Autores principales:	Jung-Hwa Ryu, Tai Yeon Koo, Han Ro, Jang-Hee Cho, Myung-Gyu Kim, Kyu Ha Huh, Jae Berm Park, Sik Lee, Seungyeup Han, Jayoun Kim, Kook-Hwan Oh, Jaeseok Yang, KNOW-KT Study group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40cbe9e6d209453abf00995a8155d9a5
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spelling	oai:doaj.org-article:40cbe9e6d209453abf00995a8155d9a52021-12-02T20:07:57ZBetter health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.1932-620310.1371/journal.pone.0257981https://doaj.org/article/40cbe9e6d209453abf00995a8155d9a52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257981https://doaj.org/toc/1932-6203Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.Jung-Hwa RyuTai Yeon KooHan RoJang-Hee ChoMyung-Gyu KimKyu Ha HuhJae Berm ParkSik LeeSeungyeup HanJayoun KimKook-Hwan OhJaeseok YangKNOW-KT Study groupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0257981 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung-Hwa Ryu Tai Yeon Koo Han Ro Jang-Hee Cho Myung-Gyu Kim Kyu Ha Huh Jae Berm Park Sik Lee Seungyeup Han Jayoun Kim Kook-Hwan Oh Jaeseok Yang KNOW-KT Study group Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
description	Renal functional deterioration is associated with physical and mental burdens for kidney transplant (KT) and chronic kidney disease (CKD) patients. However, the change in health-related quality of life (HRQOL) over time in KT patients compared to that of native CKD patients has not been evaluated. We addressed this issue using KT patients registered in the KNOW-KT cohort study and patients at CKD stage 1-3 registered in the KNOW-CKD cohort study. HRQOL scores were assessed using the Kidney Disease Quality of Life Short Form at baseline, 2-, and 4-years follow-up in 842 KT patients and at baseline and 5-year follow-up in 1,355 CKD patients. SF-36 scores declined at the 4-year follow-up, whereas CKD-targeted scores showed no change in the KT group. In contrast, CKD-targeted scores as well as SF-36 scores were decreased at the 5-year follow-up in CKD patients. When prognostic factors were analyzed for longitudinal HRQOL data over time, renal functions, diabetes, cardiovascular and cerebrovascular diseases, hemoglobin level, marital status, income, employment, and health care were significant prognostic factors. Furthermore, KT was an independent prognostic factor for better HRQOL. These results highlight that KT can offer a better HRQOL than that of CKD patients, even when renal function is similar.
format	article
author	Jung-Hwa Ryu Tai Yeon Koo Han Ro Jang-Hee Cho Myung-Gyu Kim Kyu Ha Huh Jae Berm Park Sik Lee Seungyeup Han Jayoun Kim Kook-Hwan Oh Jaeseok Yang KNOW-KT Study group
author_facet	Jung-Hwa Ryu Tai Yeon Koo Han Ro Jang-Hee Cho Myung-Gyu Kim Kyu Ha Huh Jae Berm Park Sik Lee Seungyeup Han Jayoun Kim Kook-Hwan Oh Jaeseok Yang KNOW-KT Study group
author_sort	Jung-Hwa Ryu
title	Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
title_short	Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
title_full	Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
title_fullStr	Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
title_full_unstemmed	Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
title_sort	better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/40cbe9e6d209453abf00995a8155d9a5
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Better health-related quality of life in kidney transplant patients compared to chronic kidney disease patients with similar renal function.

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