Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres

Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowi...

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Autores principales:	Joey Roosen, Mark J. Arntz, Marcel J. R. Janssen, Sytse F. de Jong, Jurgen J. Fütterer, Christiaan G. Overduin, J. Frank W. Nijsen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SIRT radioembolization holmium MRI safety compatible Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/40ccb12fd39c43ba98bf1e35ec910439
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spelling	oai:doaj.org-article:40ccb12fd39c43ba98bf1e35ec9104392021-11-11T15:33:32ZDevelopment of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres10.3390/cancers132154622072-6694https://doaj.org/article/40ccb12fd39c43ba98bf1e35ec9104392021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5462https://doaj.org/toc/2072-6694Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowing for MRI guidance during SIRT. The purpose of this study was to investigate the MRI compatibility of two angiography catheters and a microcatheter typically used for SIRT, and to explore the detectability of <sup>166</sup>Ho microspheres in a flow phantom using near real-time MRI. MR safety tests were performed at a 3 T MRI system according to American Society for Testing of Materials standard test methods. To assess the near real-time detectability of <sup>166</sup>Ho microspheres, a flow phantom was placed in the MRI bore and perfused using a peristaltic pump, simulating the flow in the hepatic artery. Dynamic MR imaging was performed using a 2D FLASH sequence during injection of different concentrations of <sup>166</sup>Ho microspheres. In the safety assessment, no significant heating (ΔT<sub>max</sub> 0.7 °C) was found in any catheter, and no magnetic interaction was found in two out of three of the used catheters. Near real-time MRI visualization of <sup>166</sup>Ho microsphere administration was feasible and depended on holmium concentration and vascular flow speed. Finally, we demonstrate preliminary imaging examples on the in vivo catheter visibility and near real-time imaging during <sup>166</sup>Ho microsphere administration in an initial patient case treated with SIRT in a clinical 3 T MRI. These results support additional research to establish the feasibility and safety of this procedure in vivo and enable the further development of a personalized MRI-guided approach to SIRT.Joey RoosenMark J. ArntzMarcel J. R. JanssenSytse F. de JongJurgen J. FüttererChristiaan G. OverduinJ. Frank W. NijsenMDPI AGarticleSIRTradioembolizationholmiumMRIsafetycompatibleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5462, p 5462 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SIRT radioembolization holmium MRI safety compatible Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	SIRT radioembolization holmium MRI safety compatible Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
description	Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (<sup>166</sup>Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowing for MRI guidance during SIRT. The purpose of this study was to investigate the MRI compatibility of two angiography catheters and a microcatheter typically used for SIRT, and to explore the detectability of <sup>166</sup>Ho microspheres in a flow phantom using near real-time MRI. MR safety tests were performed at a 3 T MRI system according to American Society for Testing of Materials standard test methods. To assess the near real-time detectability of <sup>166</sup>Ho microspheres, a flow phantom was placed in the MRI bore and perfused using a peristaltic pump, simulating the flow in the hepatic artery. Dynamic MR imaging was performed using a 2D FLASH sequence during injection of different concentrations of <sup>166</sup>Ho microspheres. In the safety assessment, no significant heating (ΔT<sub>max</sub> 0.7 °C) was found in any catheter, and no magnetic interaction was found in two out of three of the used catheters. Near real-time MRI visualization of <sup>166</sup>Ho microsphere administration was feasible and depended on holmium concentration and vascular flow speed. Finally, we demonstrate preliminary imaging examples on the in vivo catheter visibility and near real-time imaging during <sup>166</sup>Ho microsphere administration in an initial patient case treated with SIRT in a clinical 3 T MRI. These results support additional research to establish the feasibility and safety of this procedure in vivo and enable the further development of a personalized MRI-guided approach to SIRT.
format	article
author	Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen
author_facet	Joey Roosen Mark J. Arntz Marcel J. R. Janssen Sytse F. de Jong Jurgen J. Fütterer Christiaan G. Overduin J. Frank W. Nijsen
author_sort	Joey Roosen
title	Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
title_short	Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
title_full	Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
title_fullStr	Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
title_full_unstemmed	Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
title_sort	development of an mri-guided approach to selective internal radiation therapy using holmium-166 microspheres
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/40ccb12fd39c43ba98bf1e35ec910439
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Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres

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