Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease

Abstract Mean platelet volume (MPV) was recently published as a possible marker of coronary artery disease in patients at high risk for major adverse cardiac events. Because platelets play an important role in atherosclerosis, we examined the relationship between critical limb ischemia (CLI) and MPV...

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Autores principales:	Peter Rief, Reinhard B. Raggam, Alexander Avian, Franz Hafner, Mahdi Sareban, Martin Wehrschuetz, Marianne Brodmann, Thomas Gary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40cd3e5b0dc24c42a491446a7cd79dd4
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spelling	oai:doaj.org-article:40cd3e5b0dc24c42a491446a7cd79dd42021-12-02T12:32:47ZLow mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease10.1038/s41598-018-25058-82045-2322https://doaj.org/article/40cd3e5b0dc24c42a491446a7cd79dd42018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25058-8https://doaj.org/toc/2045-2322Abstract Mean platelet volume (MPV) was recently published as a possible marker of coronary artery disease in patients at high risk for major adverse cardiac events. Because platelets play an important role in atherosclerosis, we examined the relationship between critical limb ischemia (CLI) and MPV in patients with peripheral arterial occlusive disease (PAOD). Our study comprised 2124 PAOD patients. Univariate logistic regression was performed to analyze potential predictors for CLI. Nagelkerke’s R² is reported. Cross validation was performed using the leave-one-out principle. ROC analyses were performed to identify the best cut off value for MPV predicting CLI; to this end, Youden’s index was calculated. For CLI diabetes (p < 0.001, OR 2.44, 95% CI 1.97–3.02), hsCRP (p < 0.001, OR 1.01, 95% CI 1.01–1.01), age (p < 0.001, OR 1.05, 95% CI 1.04–1.06), thrombocytosis (p = 0.025, OR 1.84, 95%CI 1.08–3.14), and MPV (p = 0.003, OR 0.84, 95% CI 0.75–0.94) were significant independent predictors for CLI. ROC analysis (AUC: 0.55, 95% CI 0.52–0.58, p < 0.001) showed ≤10.2 as the best cut off value for MPV to predict CLI. As there is a significant relationship between low MPV and a high risk for CLI in PAOD patients, MPV can be used to identify patients who are likely to develop CLI.Peter RiefReinhard B. RaggamAlexander AvianFranz HafnerMahdi SarebanMartin WehrschuetzMarianne BrodmannThomas GaryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-5 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Rief Reinhard B. Raggam Alexander Avian Franz Hafner Mahdi Sareban Martin Wehrschuetz Marianne Brodmann Thomas Gary Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
description	Abstract Mean platelet volume (MPV) was recently published as a possible marker of coronary artery disease in patients at high risk for major adverse cardiac events. Because platelets play an important role in atherosclerosis, we examined the relationship between critical limb ischemia (CLI) and MPV in patients with peripheral arterial occlusive disease (PAOD). Our study comprised 2124 PAOD patients. Univariate logistic regression was performed to analyze potential predictors for CLI. Nagelkerke’s R² is reported. Cross validation was performed using the leave-one-out principle. ROC analyses were performed to identify the best cut off value for MPV predicting CLI; to this end, Youden’s index was calculated. For CLI diabetes (p < 0.001, OR 2.44, 95% CI 1.97–3.02), hsCRP (p < 0.001, OR 1.01, 95% CI 1.01–1.01), age (p < 0.001, OR 1.05, 95% CI 1.04–1.06), thrombocytosis (p = 0.025, OR 1.84, 95%CI 1.08–3.14), and MPV (p = 0.003, OR 0.84, 95% CI 0.75–0.94) were significant independent predictors for CLI. ROC analysis (AUC: 0.55, 95% CI 0.52–0.58, p < 0.001) showed ≤10.2 as the best cut off value for MPV to predict CLI. As there is a significant relationship between low MPV and a high risk for CLI in PAOD patients, MPV can be used to identify patients who are likely to develop CLI.
format	article
author	Peter Rief Reinhard B. Raggam Alexander Avian Franz Hafner Mahdi Sareban Martin Wehrschuetz Marianne Brodmann Thomas Gary
author_facet	Peter Rief Reinhard B. Raggam Alexander Avian Franz Hafner Mahdi Sareban Martin Wehrschuetz Marianne Brodmann Thomas Gary
author_sort	Peter Rief
title	Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
title_short	Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
title_full	Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
title_fullStr	Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
title_full_unstemmed	Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
title_sort	low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/40cd3e5b0dc24c42a491446a7cd79dd4
work_keys_str_mv	AT peterrief lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT reinhardbraggam lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT alexanderavian lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT franzhafner lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT mahdisareban lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT martinwehrschuetz lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT mariannebrodmann lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease AT thomasgary lowmeanplateletvolumeisassociatedwithcriticallimbischemiainperipheralarterialocclusivedisease
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Low mean platelet volume is associated with critical limb ischemia in peripheral arterial occlusive disease

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