Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

RIFINs are Plasmodium surface antigens that suppress the immune response by binding inhibitory receptors such as LAIR1. Here, Xu et al. characterize the interaction between RIFIN-variable 2 domain and a LAIR1 domain and identify LAIR1-binding RIFINs in several Plasmodium species.

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Autores principales:	Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S. Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D. Kwong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40cd63ae784a4e7da4dd3cda05cd7474
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:40cd63ae784a4e7da4dd3cda05cd74742021-12-02T16:14:57ZStructural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs10.1038/s41467-021-24291-62041-1723https://doaj.org/article/40cd63ae784a4e7da4dd3cda05cd74742021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24291-6https://doaj.org/toc/2041-1723RIFINs are Plasmodium surface antigens that suppress the immune response by binding inhibitory receptors such as LAIR1. Here, Xu et al. characterize the interaction between RIFIN-variable 2 domain and a LAIR1 domain and identify LAIR1-binding RIFINs in several Plasmodium species.Kai XuYiran WangChen-Hsiang ShenYiwei ChenBaoshan ZhangKevin LiuYaroslav TsybovskyShuishu WangS. Katie FarneyJason GormanTyler StephensRaffaello VerardiYongping YangTongqing ZhouGwo-Yu ChuangAntonio LanzavecchiaLuca PiccoliPeter D. KwongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Xu Yiran Wang Chen-Hsiang Shen Yiwei Chen Baoshan Zhang Kevin Liu Yaroslav Tsybovsky Shuishu Wang S. Katie Farney Jason Gorman Tyler Stephens Raffaello Verardi Yongping Yang Tongqing Zhou Gwo-Yu Chuang Antonio Lanzavecchia Luca Piccoli Peter D. Kwong Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
description	RIFINs are Plasmodium surface antigens that suppress the immune response by binding inhibitory receptors such as LAIR1. Here, Xu et al. characterize the interaction between RIFIN-variable 2 domain and a LAIR1 domain and identify LAIR1-binding RIFINs in several Plasmodium species.
format	article
author	Kai Xu Yiran Wang Chen-Hsiang Shen Yiwei Chen Baoshan Zhang Kevin Liu Yaroslav Tsybovsky Shuishu Wang S. Katie Farney Jason Gorman Tyler Stephens Raffaello Verardi Yongping Yang Tongqing Zhou Gwo-Yu Chuang Antonio Lanzavecchia Luca Piccoli Peter D. Kwong
author_facet	Kai Xu Yiran Wang Chen-Hsiang Shen Yiwei Chen Baoshan Zhang Kevin Liu Yaroslav Tsybovsky Shuishu Wang S. Katie Farney Jason Gorman Tyler Stephens Raffaello Verardi Yongping Yang Tongqing Zhou Gwo-Yu Chuang Antonio Lanzavecchia Luca Piccoli Peter D. Kwong
author_sort	Kai Xu
title	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
title_short	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
title_full	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
title_fullStr	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
title_full_unstemmed	Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs
title_sort	structural basis of lair1 targeting by polymorphic plasmodium rifins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40cd63ae784a4e7da4dd3cda05cd7474
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_version_	1718384286455824384

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

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