Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients

Abstract The Coronavirus disease 2019 (COVID-19) has been spreading worldwide with rapidly increased number of deaths. Hyperinflammation mediated by dysregulated monocyte/macrophage function is considered to be the key factor that triggers severe illness in COVID-19. However, no specific targeting m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyunjong Lee, Jeongbin Park, Hyung-Jun Im, Kwon Joong Na, Hongyoon Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40ce9276d8a94dcd81acfb24ba855dd4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:40ce9276d8a94dcd81acfb24ba855dd4
record_format	dspace
spelling	oai:doaj.org-article:40ce9276d8a94dcd81acfb24ba855dd42021-12-02T15:23:17ZDiscovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients10.1038/s41598-021-93743-22045-2322https://doaj.org/article/40ce9276d8a94dcd81acfb24ba855dd42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93743-2https://doaj.org/toc/2045-2322Abstract The Coronavirus disease 2019 (COVID-19) has been spreading worldwide with rapidly increased number of deaths. Hyperinflammation mediated by dysregulated monocyte/macrophage function is considered to be the key factor that triggers severe illness in COVID-19. However, no specific targeting molecule has been identified for detecting or treating hyperinflammation related to dysregulated macrophages in severe COVID-19. In this study, previously published single-cell RNA-sequencing data of bronchoalveolar lavage fluid cells from thirteen COVID-19 patients were analyzed with publicly available databases for surface and imageable targets. Immune cell composition according to the severity was estimated with the clustering of gene expression data. Expression levels of imaging target molecules for inflammation were evaluated in macrophage clusters from single-cell RNA-sequencing data. In addition, candidate targetable molecules enriched in severe COVID-19 associated with hyperinflammation were filtered. We found that expression of SLC2A3, which can be imaged by [18F]fluorodeoxyglucose, was higher in macrophages from severe COVID-19 patients. Furthermore, by integrating the surface target and drug-target binding databases with RNA-sequencing data of severe COVID-19, we identified candidate surface and druggable targets including CCR1 and FPR1 for drug delivery as well as molecular imaging. Our results provide a resource in the development of specific imaging and therapy for COVID-19-related hyperinflammation.Hyunjong LeeJeongbin ParkHyung-Jun ImKwon Joong NaHongyoon ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunjong Lee Jeongbin Park Hyung-Jun Im Kwon Joong Na Hongyoon Choi Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
description	Abstract The Coronavirus disease 2019 (COVID-19) has been spreading worldwide with rapidly increased number of deaths. Hyperinflammation mediated by dysregulated monocyte/macrophage function is considered to be the key factor that triggers severe illness in COVID-19. However, no specific targeting molecule has been identified for detecting or treating hyperinflammation related to dysregulated macrophages in severe COVID-19. In this study, previously published single-cell RNA-sequencing data of bronchoalveolar lavage fluid cells from thirteen COVID-19 patients were analyzed with publicly available databases for surface and imageable targets. Immune cell composition according to the severity was estimated with the clustering of gene expression data. Expression levels of imaging target molecules for inflammation were evaluated in macrophage clusters from single-cell RNA-sequencing data. In addition, candidate targetable molecules enriched in severe COVID-19 associated with hyperinflammation were filtered. We found that expression of SLC2A3, which can be imaged by [18F]fluorodeoxyglucose, was higher in macrophages from severe COVID-19 patients. Furthermore, by integrating the surface target and drug-target binding databases with RNA-sequencing data of severe COVID-19, we identified candidate surface and druggable targets including CCR1 and FPR1 for drug delivery as well as molecular imaging. Our results provide a resource in the development of specific imaging and therapy for COVID-19-related hyperinflammation.
format	article
author	Hyunjong Lee Jeongbin Park Hyung-Jun Im Kwon Joong Na Hongyoon Choi
author_facet	Hyunjong Lee Jeongbin Park Hyung-Jun Im Kwon Joong Na Hongyoon Choi
author_sort	Hyunjong Lee
title	Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
title_short	Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
title_full	Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
title_fullStr	Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
title_full_unstemmed	Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients
title_sort	discovery of potential imaging and therapeutic targets for severe inflammation in covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40ce9276d8a94dcd81acfb24ba855dd4
work_keys_str_mv	AT hyunjonglee discoveryofpotentialimagingandtherapeutictargetsforsevereinflammationincovid19patients AT jeongbinpark discoveryofpotentialimagingandtherapeutictargetsforsevereinflammationincovid19patients AT hyungjunim discoveryofpotentialimagingandtherapeutictargetsforsevereinflammationincovid19patients AT kwonjoongna discoveryofpotentialimagingandtherapeutictargetsforsevereinflammationincovid19patients AT hongyoonchoi discoveryofpotentialimagingandtherapeutictargetsforsevereinflammationincovid19patients
_version_	1718387259315585024

Discovery of potential imaging and therapeutic targets for severe inflammation in COVID-19 patients

Ejemplares similares