EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI transcriptional program in neighbouring epithelial tumo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis, Heide L. Ford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40cf1e9c00f54d94942b4feaef93dd57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:40cf1e9c00f54d94942b4feaef93dd57
record_format	dspace
spelling	oai:doaj.org-article:40cf1e9c00f54d94942b4feaef93dd572021-12-02T14:42:18ZEMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells10.1038/ncomms157732041-1723https://doaj.org/article/40cf1e9c00f54d94942b4feaef93dd572017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15773https://doaj.org/toc/2041-1723Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI transcriptional program in neighbouring epithelial tumour cells.Deepika NeelakantanHengbo ZhouMichael U. J. OliphantXiaomei ZhangLukas M. SimonDavid M. HenkeChad A. ShawMeng-Fen WuSusan G. HilsenbeckLisa D. WhiteMichael T. LewisHeide L. FordNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepika Neelakantan Hengbo Zhou Michael U. J. Oliphant Xiaomei Zhang Lukas M. Simon David M. Henke Chad A. Shaw Meng-Fen Wu Susan G. Hilsenbeck Lisa D. White Michael T. Lewis Heide L. Ford EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
description	Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI transcriptional program in neighbouring epithelial tumour cells.
format	article
author	Deepika Neelakantan Hengbo Zhou Michael U. J. Oliphant Xiaomei Zhang Lukas M. Simon David M. Henke Chad A. Shaw Meng-Fen Wu Susan G. Hilsenbeck Lisa D. White Michael T. Lewis Heide L. Ford
author_facet	Deepika Neelakantan Hengbo Zhou Michael U. J. Oliphant Xiaomei Zhang Lukas M. Simon David M. Henke Chad A. Shaw Meng-Fen Wu Susan G. Hilsenbeck Lisa D. White Michael T. Lewis Heide L. Ford
author_sort	Deepika Neelakantan
title	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
title_short	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
title_full	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
title_fullStr	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
title_full_unstemmed	EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells
title_sort	emt cells increase breast cancer metastasis via paracrine gli activation in neighbouring tumour cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40cf1e9c00f54d94942b4feaef93dd57
work_keys_str_mv	AT deepikaneelakantan emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT hengbozhou emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT michaelujoliphant emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT xiaomeizhang emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT lukasmsimon emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT davidmhenke emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT chadashaw emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT mengfenwu emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT susanghilsenbeck emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT lisadwhite emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT michaeltlewis emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells AT heidelford emtcellsincreasebreastcancermetastasisviaparacrinegliactivationinneighbouringtumourcells
_version_	1718389744955555840

EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Ejemplares similares