EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

Recent findings have challenged the centrality of epithelial-to-mesenchymal transition (EMT) in promoting tumour progression. Here the authors show that EMT cells can promote breast cancer metastasis by non-cell autonomous activation of the GLI transcriptional program in neighbouring epithelial tumo...

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Auteurs principaux: Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis, Heide L. Ford
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/40cf1e9c00f54d94942b4feaef93dd57
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