Inflammation-induced Id2 promotes plasticity in regulatory T cells

Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the trans...

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Bibliographic Details
Main Authors: Sung-Min Hwang, Garima Sharma, Ravi Verma, Seohyun Byun, Dipayan Rudra, Sin-Hyeog Im
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/40cfc8c8e29e492fa639acc455be2eb3
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Summary:Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.