Inflammation-induced Id2 promotes plasticity in regulatory T cells

Inflammation-induced Id2 promotes plasticity in regulatory T cells

Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the trans...

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Autores principales: Sung-Min Hwang, Garima Sharma, Ravi Verma, Seohyun Byun, Dipayan Rudra, Sin-Hyeog Im
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/40cfc8c8e29e492fa639acc455be2eb3
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spelling oai:doaj.org-article:40cfc8c8e29e492fa639acc455be2eb32021-12-02T15:33:41ZInflammation-induced Id2 promotes plasticity in regulatory T cells10.1038/s41467-018-07254-22041-1723https://doaj.org/article/40cfc8c8e29e492fa639acc455be2eb32018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07254-2https://doaj.org/toc/2041-1723Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.Sung-Min HwangGarima SharmaRavi VermaSeohyun ByunDipayan RudraSin-Hyeog ImNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
Inflammation-induced Id2 promotes plasticity in regulatory T cells
description Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.
format article
author Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
author_facet Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
author_sort Sung-Min Hwang
title Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_short Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_full Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_fullStr Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_full_unstemmed Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_sort inflammation-induced id2 promotes plasticity in regulatory t cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/40cfc8c8e29e492fa639acc455be2eb3
work_keys_str_mv AT sungminhwang inflammationinducedid2promotesplasticityinregulatorytcells
AT garimasharma inflammationinducedid2promotesplasticityinregulatorytcells
AT raviverma inflammationinducedid2promotesplasticityinregulatorytcells
AT seohyunbyun inflammationinducedid2promotesplasticityinregulatorytcells
AT dipayanrudra inflammationinducedid2promotesplasticityinregulatorytcells
AT sinhyeogim inflammationinducedid2promotesplasticityinregulatorytcells
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