Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives

A carboxyl-terminated fullerene pyrrolidine derivative was synthesized by 1, 3-dipolar cycloaddition of imine ylide (FP-COOH). UV-Vis, FT-IR and MALDI-TOF respectively verified the effective synthesis of compounds. The compound (FP-COOH) was used as an intermediate, and then the hydrothermal chemica...

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Autores principales:	Ying WANG, Li SU, Bing LI, Ningning JIN, Riji LU, Jing ZHANG
Formato:	article
Lenguaje:	EN
Publicado:	Kaunas University of Technology 2021
Materias:	carboxyl-terminated fullerene pyrrolidine iron oxide magnetic targeting oxorubicin Mining engineering. Metallurgy TN1-997
Acceso en línea:	https://doaj.org/article/40d39d36112c44398503195192ed4132
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spelling	oai:doaj.org-article:40d39d36112c44398503195192ed41322021-11-20T07:34:17ZResearch on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives1392-13202029-728910.5755/j02.ms.24918https://doaj.org/article/40d39d36112c44398503195192ed41322021-11-01T00:00:00Zhttps://matsc.ktu.lt/index.php/MatSc/article/view/24918https://doaj.org/toc/1392-1320https://doaj.org/toc/2029-7289A carboxyl-terminated fullerene pyrrolidine derivative was synthesized by 1, 3-dipolar cycloaddition of imine ylide (FP-COOH). UV-Vis, FT-IR and MALDI-TOF respectively verified the effective synthesis of compounds. The compound (FP-COOH) was used as an intermediate, and then the hydrothermal chemical bonding method was used to load ferric oxide on the compound (FP-COOH). Its purpose was to form a magnetic targeting carrier system (FP-IONP-COOH). Then use the non-covalent method to combine FP-IONP-COOH with doxorubicin. The ultimate goal was to improve the side effects of doxorubicin. The solubility experiments showed that both FP-IONP-COOH and FP-IONP-COOH/DOX had good water solubility. The investigation of magnetism showed that FP-IONP-COOH has good magnetism. Finally, in vitro release experiments further verified the targeting of FP-IONP-COOH/DOX. The cumulative release of DOX at 48 h could be as high as 82 %, whereas the accumulated release of FP-IONP-COOH/DOX at 48 h was only 48 %, and was able to continuously release for more than 120 h, demonstrating its good sustained release in vivo.Ying WANGLi SUBing LINingning JINRiji LUJing ZHANGKaunas University of Technologyarticlecarboxyl-terminated fullerene pyrrolidineiron oxidemagnetic targetingoxorubicinMining engineering. MetallurgyTN1-997ENMedžiagotyra, Vol 27, Iss 4, Pp 444-450 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carboxyl-terminated fullerene pyrrolidine iron oxide magnetic targeting oxorubicin Mining engineering. Metallurgy TN1-997
spellingShingle	carboxyl-terminated fullerene pyrrolidine iron oxide magnetic targeting oxorubicin Mining engineering. Metallurgy TN1-997 Ying WANG Li SU Bing LI Ningning JIN Riji LU Jing ZHANG Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
description	A carboxyl-terminated fullerene pyrrolidine derivative was synthesized by 1, 3-dipolar cycloaddition of imine ylide (FP-COOH). UV-Vis, FT-IR and MALDI-TOF respectively verified the effective synthesis of compounds. The compound (FP-COOH) was used as an intermediate, and then the hydrothermal chemical bonding method was used to load ferric oxide on the compound (FP-COOH). Its purpose was to form a magnetic targeting carrier system (FP-IONP-COOH). Then use the non-covalent method to combine FP-IONP-COOH with doxorubicin. The ultimate goal was to improve the side effects of doxorubicin. The solubility experiments showed that both FP-IONP-COOH and FP-IONP-COOH/DOX had good water solubility. The investigation of magnetism showed that FP-IONP-COOH has good magnetism. Finally, in vitro release experiments further verified the targeting of FP-IONP-COOH/DOX. The cumulative release of DOX at 48 h could be as high as 82 %, whereas the accumulated release of FP-IONP-COOH/DOX at 48 h was only 48 %, and was able to continuously release for more than 120 h, demonstrating its good sustained release in vivo.
format	article
author	Ying WANG Li SU Bing LI Ningning JIN Riji LU Jing ZHANG
author_facet	Ying WANG Li SU Bing LI Ningning JIN Riji LU Jing ZHANG
author_sort	Ying WANG
title	Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
title_short	Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
title_full	Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
title_fullStr	Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
title_full_unstemmed	Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives
title_sort	research on magnetically targeted drug delivery system based on fullerene derivatives
publisher	Kaunas University of Technology
publishDate	2021
url	https://doaj.org/article/40d39d36112c44398503195192ed4132
work_keys_str_mv	AT yingwang researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives AT lisu researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives AT bingli researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives AT ningningjin researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives AT rijilu researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives AT jingzhang researchonmagneticallytargeteddrugdeliverysystembasedonfullerenederivatives
_version_	1718419477227372544

Research on Magnetically Targeted Drug Delivery System Based on Fullerene Derivatives

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