Design aspects of the combined medicinal product with multifunctional action based on herbal drugs

Combined herbal medicines for the treatment and prevention of allergic diseases are perspective substitutes for the «classic» drugs of H-1 receptor blockers of the 1st and 2nd generation. Literary-logical methods are quite effectively used for scientifically justified design of these drugs, namely p...

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Autores principales:	S. A. Kotov, T. M. Gontova, A. G. Kotov
Formato:	article
Lenguaje:	UK
Publicado:	The State Expert Center of the Ministry of Health of Ukraine 2021
Materias:	bur-marigold herb calendula flowers hawthorn leaf and flowers phytochemical design phytopharmacological design spirmen’s coefficient of correlation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/40d53f77b503466c8b63f328f4916a88
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spelling	oai:doaj.org-article:40d53f77b503466c8b63f328f4916a882021-11-04T12:24:16ZDesign aspects of the combined medicinal product with multifunctional action based on herbal drugs10.32352/0367-3057.5.21.060367-30572617-9628https://doaj.org/article/40d53f77b503466c8b63f328f4916a882021-10-01T00:00:00Zhttps://pharmj.org.ua/index.php/journal/article/view/1248/1172https://doaj.org/toc/0367-3057https://doaj.org/toc/2617-9628Combined herbal medicines for the treatment and prevention of allergic diseases are perspective substitutes for the «classic» drugs of H-1 receptor blockers of the 1st and 2nd generation. Literary-logical methods are quite effectively used for scientifically justified design of these drugs, namely phytopharmacological drug design (PPD) and phytochemical drug design (PCD). The aim of the work – the search for ways of the scientifically justified design of a combined multifunctional medicine based on the bur-marigold, which normalizes the functioning of the body's defence systems, increases the body's nonspecific resistance, normalizes the immune status using literary-logical and statistical methods of analysis. The design of the preparation was carried out using literature data for PPD and experimental and literature data for PCD. Statistical processing method – Spearman's rank correlation coefficient was used. Design aspects of the combined herbal medicine, which includes a bur-marigold herb, calendula flowers, hawthorn leaves and flowers were considered using of a system-comparative analysis of information and its processing by the method of the Spearman's rank correlation coefficient determination. When PCD development of various combinations of herbal drugs, information about the content of such biologically active substances (BAS) as flavonoids, oxycinnamic acids, polyphenols, triterpenes, proteins/amino acids, polysaccharides was used. When PPD development the spectra of pharmacological activity were determined and a quantitative assessment to them in the system of marks for each of the herbal drug of the combined medicine was given. The PCD and PPD data into the matrix for calculating the Spearman rank correlation coefficient of the «action–sum of BAS» was entered. As a result, a strong, direct and statistically significant correlation relation (p from 0.924 to 0.997) between the content of oxycinnamic acids, polyphenols, triterpenes, proteins/amino acids, polysaccharides and such pharmacological actions as capillary-strengthening, anti-inflammatory, immunostimulating; choleretic, hepatoprotective, improving metabolism; diuretic, hypotensive, sedative, tonic, desensitizing, antipruritic, reparative for the studied herbal combinations was found. The obtained results of the PCD and PPD development as well as the study of the correlation «action–sum of BAS» by calculating the Spearman's rank correlation coefficient, this suggests the developed combined herbal medicinal product with multifunctional action is perspective in the complex therapy of allergic diseases accompanied by a decrease in the body's resistance and immunostatus.S. A. KotovT. M. GontovaA. G. KotovThe State Expert Center of the Ministry of Health of Ukrainearticlebur-marigold herbcalendula flowershawthorn leaf and flowersphytochemical designphytopharmacological designspirmen’s coefficient of correlationTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441UKФармацевтичний журнал, Vol 5, Pp 57-67 (2021)
institution	DOAJ
collection	DOAJ
language	UK
topic	bur-marigold herb calendula flowers hawthorn leaf and flowers phytochemical design phytopharmacological design spirmen’s coefficient of correlation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	bur-marigold herb calendula flowers hawthorn leaf and flowers phytochemical design phytopharmacological design spirmen’s coefficient of correlation Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 S. A. Kotov T. M. Gontova A. G. Kotov Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
description	Combined herbal medicines for the treatment and prevention of allergic diseases are perspective substitutes for the «classic» drugs of H-1 receptor blockers of the 1st and 2nd generation. Literary-logical methods are quite effectively used for scientifically justified design of these drugs, namely phytopharmacological drug design (PPD) and phytochemical drug design (PCD). The aim of the work – the search for ways of the scientifically justified design of a combined multifunctional medicine based on the bur-marigold, which normalizes the functioning of the body's defence systems, increases the body's nonspecific resistance, normalizes the immune status using literary-logical and statistical methods of analysis. The design of the preparation was carried out using literature data for PPD and experimental and literature data for PCD. Statistical processing method – Spearman's rank correlation coefficient was used. Design aspects of the combined herbal medicine, which includes a bur-marigold herb, calendula flowers, hawthorn leaves and flowers were considered using of a system-comparative analysis of information and its processing by the method of the Spearman's rank correlation coefficient determination. When PCD development of various combinations of herbal drugs, information about the content of such biologically active substances (BAS) as flavonoids, oxycinnamic acids, polyphenols, triterpenes, proteins/amino acids, polysaccharides was used. When PPD development the spectra of pharmacological activity were determined and a quantitative assessment to them in the system of marks for each of the herbal drug of the combined medicine was given. The PCD and PPD data into the matrix for calculating the Spearman rank correlation coefficient of the «action–sum of BAS» was entered. As a result, a strong, direct and statistically significant correlation relation (p from 0.924 to 0.997) between the content of oxycinnamic acids, polyphenols, triterpenes, proteins/amino acids, polysaccharides and such pharmacological actions as capillary-strengthening, anti-inflammatory, immunostimulating; choleretic, hepatoprotective, improving metabolism; diuretic, hypotensive, sedative, tonic, desensitizing, antipruritic, reparative for the studied herbal combinations was found. The obtained results of the PCD and PPD development as well as the study of the correlation «action–sum of BAS» by calculating the Spearman's rank correlation coefficient, this suggests the developed combined herbal medicinal product with multifunctional action is perspective in the complex therapy of allergic diseases accompanied by a decrease in the body's resistance and immunostatus.
format	article
author	S. A. Kotov T. M. Gontova A. G. Kotov
author_facet	S. A. Kotov T. M. Gontova A. G. Kotov
author_sort	S. A. Kotov
title	Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
title_short	Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
title_full	Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
title_fullStr	Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
title_full_unstemmed	Design aspects of the combined medicinal product with multifunctional action based on herbal drugs
title_sort	design aspects of the combined medicinal product with multifunctional action based on herbal drugs
publisher	The State Expert Center of the Ministry of Health of Ukraine
publishDate	2021
url	https://doaj.org/article/40d53f77b503466c8b63f328f4916a88
work_keys_str_mv	AT sakotov designaspectsofthecombinedmedicinalproductwithmultifunctionalactionbasedonherbaldrugs AT tmgontova designaspectsofthecombinedmedicinalproductwithmultifunctionalactionbasedonherbaldrugs AT agkotov designaspectsofthecombinedmedicinalproductwithmultifunctionalactionbasedonherbaldrugs
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Design aspects of the combined medicinal product with multifunctional action based on herbal drugs

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