Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats

Lifestyle improvement, including through exercise, has been recognized as an important mode of therapy for the suppression of diabetic kidney disease (DKD). However, the detailed molecular mechanisms by which exercise exerts beneficial effects in the suppression of DKD have not yet been fully elucid...

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Autores principales:	Itaru Monno, Yoshio Ogura, Jing Xu, Daisuke Koya, Munehiro Kitada
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	diabetic kidney disease exercise inflammation oxidative stress autophagy AMP-activated kinase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/40d9f28502d04529b2982ebb9938ff98
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spelling	oai:doaj.org-article:40d9f28502d04529b2982ebb9938ff982021-11-25T16:27:53ZExercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats10.3390/antiox101117542076-3921https://doaj.org/article/40d9f28502d04529b2982ebb9938ff982021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1754https://doaj.org/toc/2076-3921Lifestyle improvement, including through exercise, has been recognized as an important mode of therapy for the suppression of diabetic kidney disease (DKD). However, the detailed molecular mechanisms by which exercise exerts beneficial effects in the suppression of DKD have not yet been fully elucidated. In this study, we investigate the effects of treadmill exercise training (TET) for 8 weeks (13 m/min, 30 min/day, 5 days/week) on kidney injuries of type 2 diabetic male rats with obesity (Wistar fatty (fa/fa) rats: WFRs) at 36 weeks of age. TET significantly suppressed the levels of albuminuria and urinary liver-type fatty-acid-binding protein (L-FABP), tubulointerstitial fibrosis, inflammation, and oxidative stress in the kidneys of WFRs. In addition, TET mitigated excessive apoptosis and restored autophagy in the renal cortex, as well as suppressed the development of morphological abnormalities in the mitochondria of proximal tubular cells, which were also accompanied by the restoration of AMP-activated kinase (AMPK) activity and suppression of the mechanistic target of rapamycin complex 1 (mTORC1). In conclusion, TET ameliorates diabetes-induced kidney injury in type 2 diabetic fatty rats.Itaru MonnoYoshio OguraJing XuDaisuke KoyaMunehiro KitadaMDPI AGarticlediabetic kidney diseaseexerciseinflammationoxidative stressautophagyAMP-activated kinaseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1754, p 1754 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic kidney disease exercise inflammation oxidative stress autophagy AMP-activated kinase Therapeutics. Pharmacology RM1-950
spellingShingle	diabetic kidney disease exercise inflammation oxidative stress autophagy AMP-activated kinase Therapeutics. Pharmacology RM1-950 Itaru Monno Yoshio Ogura Jing Xu Daisuke Koya Munehiro Kitada Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
description	Lifestyle improvement, including through exercise, has been recognized as an important mode of therapy for the suppression of diabetic kidney disease (DKD). However, the detailed molecular mechanisms by which exercise exerts beneficial effects in the suppression of DKD have not yet been fully elucidated. In this study, we investigate the effects of treadmill exercise training (TET) for 8 weeks (13 m/min, 30 min/day, 5 days/week) on kidney injuries of type 2 diabetic male rats with obesity (Wistar fatty (fa/fa) rats: WFRs) at 36 weeks of age. TET significantly suppressed the levels of albuminuria and urinary liver-type fatty-acid-binding protein (L-FABP), tubulointerstitial fibrosis, inflammation, and oxidative stress in the kidneys of WFRs. In addition, TET mitigated excessive apoptosis and restored autophagy in the renal cortex, as well as suppressed the development of morphological abnormalities in the mitochondria of proximal tubular cells, which were also accompanied by the restoration of AMP-activated kinase (AMPK) activity and suppression of the mechanistic target of rapamycin complex 1 (mTORC1). In conclusion, TET ameliorates diabetes-induced kidney injury in type 2 diabetic fatty rats.
format	article
author	Itaru Monno Yoshio Ogura Jing Xu Daisuke Koya Munehiro Kitada
author_facet	Itaru Monno Yoshio Ogura Jing Xu Daisuke Koya Munehiro Kitada
author_sort	Itaru Monno
title	Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
title_short	Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
title_full	Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
title_fullStr	Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
title_full_unstemmed	Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats
title_sort	exercise ameliorates diabetic kidney disease in type 2 diabetic fatty rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/40d9f28502d04529b2982ebb9938ff98
work_keys_str_mv	AT itarumonno exerciseamelioratesdiabetickidneydiseaseintype2diabeticfattyrats AT yoshioogura exerciseamelioratesdiabetickidneydiseaseintype2diabeticfattyrats AT jingxu exerciseamelioratesdiabetickidneydiseaseintype2diabeticfattyrats AT daisukekoya exerciseamelioratesdiabetickidneydiseaseintype2diabeticfattyrats AT munehirokitada exerciseamelioratesdiabetickidneydiseaseintype2diabeticfattyrats
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Exercise Ameliorates Diabetic Kidney Disease in Type 2 Diabetic Fatty Rats

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