Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice

Objective: In traditional medicine, some plants have been used as analgesic. The aim of this investigation was to evaluate the analgesic effect of “Pimpinella Anisun” that is used traditionally to relieve headache and spastic pain. Methods: The seuhleted and percolated extracts of Pimpinella Anisun,...

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Autores principales:	MR Heidari, A Asadi Pour, Gh Sepehri, N Atapour, Esmaeili
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 1999
Materias:	medicinal plants pimpinella anisun pain measurement formalin test tail-flick Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/40da397f081a438493d4067b365f42b6
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spelling	oai:doaj.org-article:40da397f081a438493d4067b365f42b62021-11-10T09:24:24ZStudy of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice1561-41072251-7170https://doaj.org/article/40da397f081a438493d4067b365f42b61999-07-01T00:00:00Zhttp://jbums.org/article-1-2950-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: In traditional medicine, some plants have been used as analgesic. The aim of this investigation was to evaluate the analgesic effect of “Pimpinella Anisun” that is used traditionally to relieve headache and spastic pain. Methods: The seuhleted and percolated extracts of Pimpinella Anisun, with different doses, were injected intraperitoneally (IP) to mice and the analgesic effect was determined by tail-flick and Formalin test. Findings: The results show that suxhulated extract with doses of (25, 50, 100 and 200 mg/kg), induce significant analgesia in comparison with control group (P<0.01). In tail-flick test, the maximum analgesia was induced with the dose of 50 mg/kg and reached high to a peak at 45th min. after injection (P<0.01). The extract with the dose of 50 mg/kg induced analgesia in Formalin test at a different time (P<0.01) than in 0-5 min. There is no difference between the analgesic effect of morphine and extract at 10-15 min. in Formalin test, but at the first and second 5 min, the analgesic effect of extract was smaller than morphine (P<0.01) and was greater at 15-20 and 20-55 min. (P<0.01). There is no difference between the analgesic effect of extract and ASA 300 mg/kg at the first 5 minutes and 25-30, but at the second 5 minutes, the effect of extract was smaller (P<0.01) but it was greater than ASA at other times (P<0.01). Pretreatment of animals with naloxone did not change the analgesic effect of extract in the Formalin and tail-flick. Conclusion: This finding indicates that the involvement of opioid receptors in the analgesic effect of extract was excluded. In this investigation the suitable analgesic effect was seen from the extract of Pimpinella Anisun and therefore more investigation in this filed is needed.MR HeidariA Asadi PourGh SepehriN AtapourEsmaeiliBabol University of Medical Sciencesarticlemedicinal plantspimpinella anisunpain measurementformalin testtail-flickMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 1, Iss 3, Pp 42-51 (1999)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	medicinal plants pimpinella anisun pain measurement formalin test tail-flick Medicine R Medicine (General) R5-920
spellingShingle	medicinal plants pimpinella anisun pain measurement formalin test tail-flick Medicine R Medicine (General) R5-920 MR Heidari A Asadi Pour Gh Sepehri N Atapour Esmaeili Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
description	Objective: In traditional medicine, some plants have been used as analgesic. The aim of this investigation was to evaluate the analgesic effect of “Pimpinella Anisun” that is used traditionally to relieve headache and spastic pain. Methods: The seuhleted and percolated extracts of Pimpinella Anisun, with different doses, were injected intraperitoneally (IP) to mice and the analgesic effect was determined by tail-flick and Formalin test. Findings: The results show that suxhulated extract with doses of (25, 50, 100 and 200 mg/kg), induce significant analgesia in comparison with control group (P<0.01). In tail-flick test, the maximum analgesia was induced with the dose of 50 mg/kg and reached high to a peak at 45th min. after injection (P<0.01). The extract with the dose of 50 mg/kg induced analgesia in Formalin test at a different time (P<0.01) than in 0-5 min. There is no difference between the analgesic effect of morphine and extract at 10-15 min. in Formalin test, but at the first and second 5 min, the analgesic effect of extract was smaller than morphine (P<0.01) and was greater at 15-20 and 20-55 min. (P<0.01). There is no difference between the analgesic effect of extract and ASA 300 mg/kg at the first 5 minutes and 25-30, but at the second 5 minutes, the effect of extract was smaller (P<0.01) but it was greater than ASA at other times (P<0.01). Pretreatment of animals with naloxone did not change the analgesic effect of extract in the Formalin and tail-flick. Conclusion: This finding indicates that the involvement of opioid receptors in the analgesic effect of extract was excluded. In this investigation the suitable analgesic effect was seen from the extract of Pimpinella Anisun and therefore more investigation in this filed is needed.
format	article
author	MR Heidari A Asadi Pour Gh Sepehri N Atapour Esmaeili
author_facet	MR Heidari A Asadi Pour Gh Sepehri N Atapour Esmaeili
author_sort	MR Heidari
title	Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
title_short	Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
title_full	Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
title_fullStr	Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
title_full_unstemmed	Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice
title_sort	study of the analgesic effect of pimpinella anisun extract by tail-flick and formalin test in mice
publisher	Babol University of Medical Sciences
publishDate	1999
url	https://doaj.org/article/40da397f081a438493d4067b365f42b6
work_keys_str_mv	AT mrheidari studyoftheanalgesiceffectofpimpinellaanisunextractbytailflickandformalintestinmice AT aasadipour studyoftheanalgesiceffectofpimpinellaanisunextractbytailflickandformalintestinmice AT ghsepehri studyoftheanalgesiceffectofpimpinellaanisunextractbytailflickandformalintestinmice AT natapour studyoftheanalgesiceffectofpimpinellaanisunextractbytailflickandformalintestinmice AT esmaeili studyoftheanalgesiceffectofpimpinellaanisunextractbytailflickandformalintestinmice
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Study of the analgesic effect of Pimpinella Anisun extract by Tail-Flick and Formalin test in mice

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