Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway

The mechanism by which environmental pH controls the virulence of the pathogen Streptococcus pyogenes is unclear. Here, Do et al. show that changes in pH affect the activity of the virulence regulator RopB via its interaction with a quorum-sensing peptide signal.

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Autores principales:	Hackwon Do, Nishanth Makthal, Arica R. VanderWal, Matthew Ojeda Saavedra, Randall J. Olsen, James M. Musser, Muthiah Kumaraswami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40db01e1de754e5f889efcd573d36d94
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spelling	oai:doaj.org-article:40db01e1de754e5f889efcd573d36d942021-12-02T15:35:56ZEnvironmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway10.1038/s41467-019-10556-82041-1723https://doaj.org/article/40db01e1de754e5f889efcd573d36d942019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10556-8https://doaj.org/toc/2041-1723The mechanism by which environmental pH controls the virulence of the pathogen Streptococcus pyogenes is unclear. Here, Do et al. show that changes in pH affect the activity of the virulence regulator RopB via its interaction with a quorum-sensing peptide signal.Hackwon DoNishanth MakthalArica R. VanderWalMatthew Ojeda SaavedraRandall J. OlsenJames M. MusserMuthiah KumaraswamiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hackwon Do Nishanth Makthal Arica R. VanderWal Matthew Ojeda Saavedra Randall J. Olsen James M. Musser Muthiah Kumaraswami Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
description	The mechanism by which environmental pH controls the virulence of the pathogen Streptococcus pyogenes is unclear. Here, Do et al. show that changes in pH affect the activity of the virulence regulator RopB via its interaction with a quorum-sensing peptide signal.
format	article
author	Hackwon Do Nishanth Makthal Arica R. VanderWal Matthew Ojeda Saavedra Randall J. Olsen James M. Musser Muthiah Kumaraswami
author_facet	Hackwon Do Nishanth Makthal Arica R. VanderWal Matthew Ojeda Saavedra Randall J. Olsen James M. Musser Muthiah Kumaraswami
author_sort	Hackwon Do
title	Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
title_short	Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
title_full	Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
title_fullStr	Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
title_full_unstemmed	Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway
title_sort	environmental ph and peptide signaling control virulence of streptococcus pyogenes via a quorum-sensing pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/40db01e1de754e5f889efcd573d36d94
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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway

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