A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City

A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City

ABSTRACT Ceftazidime-avibactam is a potent antibiotic combination against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Here, we describe a unique ceftazidime-avibactam-resistant and carbapenem-susceptible K. pneumoniae strain harboring a novel blaKPC-14 variant. This strai...

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Autores principales: Siqiang Niu, Kalyan D. Chavda, Jie Wei, Chunhong Zou, Steven H. Marshall, Puneet Dhawan, Deqiang Wang, Robert A. Bonomo, Barry N. Kreiswirth, Liang Chen
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
ceftazidime-avibactam
carbapenem
KPC
plasmid
antimicrobial resistance
selection
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/40e485492bcf413eb8277942167c5e36
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spelling oai:doaj.org-article:40e485492bcf413eb8277942167c5e362021-11-15T15:30:51ZA Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City10.1128/mSphere.00775-202379-5042https://doaj.org/article/40e485492bcf413eb8277942167c5e362020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00775-20https://doaj.org/toc/2379-5042ABSTRACT Ceftazidime-avibactam is a potent antibiotic combination against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Here, we describe a unique ceftazidime-avibactam-resistant and carbapenem-susceptible K. pneumoniae strain harboring a novel blaKPC-14 variant. This strain was isolated from a New York City patient in 2003, which predates the introduction of avibactam. Despite resistance to ceftazidime-avibactam, the strain was susceptible to imipenem-relebactam and meropenem-vaborbactam. Comprehensive genomic sequencing revealed that blaKPC-14 is harbored on an ST6 IncN plasmid associated with the early spread of blaKPC. IMPORTANCE KPC is currently the most common carbapenemase identified in the United States. More than 40 KPC variants have been described, of which KPC-2 and KPC-3 are the most frequent clinical variants. However, our understanding of the genetic structures and β-lactam resistance profiles of other novel KPC variants remains incomplete. Here, we report a novel blaKPC variant (blaKPC-14) and the complete genome sequence of blaKPC-14-harboring K. pneumoniae strain BK13048, which is susceptible to carbapenems but resistant to ceftazidime-avibactam. To the best of our knowledge, this is one of the earliest KPC-producing K. pneumoniae strains exhibiting resistance to ceftazidime-avibactam.Siqiang NiuKalyan D. ChavdaJie WeiChunhong ZouSteven H. MarshallPuneet DhawanDeqiang WangRobert A. BonomoBarry N. KreiswirthLiang ChenAmerican Society for Microbiologyarticleceftazidime-avibactamcarbapenemKPCplasmidantimicrobial resistanceselectionMicrobiologyQR1-502ENmSphere, Vol 5, Iss 4 (2020)
institution DOAJ
collection DOAJ
language EN
topic ceftazidime-avibactam
carbapenem
KPC
plasmid
antimicrobial resistance
selection
Microbiology
QR1-502
spellingShingle ceftazidime-avibactam
carbapenem
KPC
plasmid
antimicrobial resistance
selection
Microbiology
QR1-502
Siqiang Niu
Kalyan D. Chavda
Jie Wei
Chunhong Zou
Steven H. Marshall
Puneet Dhawan
Deqiang Wang
Robert A. Bonomo
Barry N. Kreiswirth
Liang Chen
A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
description ABSTRACT Ceftazidime-avibactam is a potent antibiotic combination against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Here, we describe a unique ceftazidime-avibactam-resistant and carbapenem-susceptible K. pneumoniae strain harboring a novel blaKPC-14 variant. This strain was isolated from a New York City patient in 2003, which predates the introduction of avibactam. Despite resistance to ceftazidime-avibactam, the strain was susceptible to imipenem-relebactam and meropenem-vaborbactam. Comprehensive genomic sequencing revealed that blaKPC-14 is harbored on an ST6 IncN plasmid associated with the early spread of blaKPC. IMPORTANCE KPC is currently the most common carbapenemase identified in the United States. More than 40 KPC variants have been described, of which KPC-2 and KPC-3 are the most frequent clinical variants. However, our understanding of the genetic structures and β-lactam resistance profiles of other novel KPC variants remains incomplete. Here, we report a novel blaKPC variant (blaKPC-14) and the complete genome sequence of blaKPC-14-harboring K. pneumoniae strain BK13048, which is susceptible to carbapenems but resistant to ceftazidime-avibactam. To the best of our knowledge, this is one of the earliest KPC-producing K. pneumoniae strains exhibiting resistance to ceftazidime-avibactam.
format article
author Siqiang Niu
Kalyan D. Chavda
Jie Wei
Chunhong Zou
Steven H. Marshall
Puneet Dhawan
Deqiang Wang
Robert A. Bonomo
Barry N. Kreiswirth
Liang Chen
author_facet Siqiang Niu
Kalyan D. Chavda
Jie Wei
Chunhong Zou
Steven H. Marshall
Puneet Dhawan
Deqiang Wang
Robert A. Bonomo
Barry N. Kreiswirth
Liang Chen
author_sort Siqiang Niu
title A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
title_short A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
title_full A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
title_fullStr A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
title_full_unstemmed A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> Strain Harboring <italic toggle="yes">bla</italic><sub>KPC-14</sub> Isolated in New York City
title_sort ceftazidime-avibactam-resistant and carbapenem-susceptible <named-content content-type="genus-species">klebsiella pneumoniae</named-content> strain harboring <italic toggle="yes">bla</italic><sub>kpc-14</sub> isolated in new york city
publisher American Society for Microbiology
publishDate 2020
url https://doaj.org/article/40e485492bcf413eb8277942167c5e36
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