Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH

The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, ha...

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Autores principales:	Yohei Takeda, Sachiko Matsuda, Dulamjav Jamsransuren, Haruko Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	IWA Publishing 2021
Materias:	disinfectant hypochlorous acid water manufacturing method ph sars-cov-2 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/40e69f7527bd4edc88063dc2d3600cf8
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spelling	oai:doaj.org-article:40e69f7527bd4edc88063dc2d3600cf82021-11-06T06:05:08ZComparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH1477-89201996-782910.2166/wh.2021.260https://doaj.org/article/40e69f7527bd4edc88063dc2d3600cf82021-06-01T00:00:00Zhttp://jwh.iwaponline.com/content/19/3/448https://doaj.org/toc/1477-8920https://doaj.org/toc/1996-7829The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. However, different manufacturing methods have produced several HAW products with various pH values. Here, we compared the SARS-CoV-2-inactivating activities of various HAW products. At sufficiently high volume and residual chlorine concentration (RCC), the HAW products inactivated SARS-CoV-2 efficiently regardless of pH or manufacturing method. However, although HAW products at pH 5.0–6.4 maintained high RCC and sustained virucidal activity for 21 days, the RCC rapidly decreased in HAW products at pH ≤ 3.0. Our results may guide in choosing appropriate HAW products for different usage situations. HIGHLIGHTS Hypochlorous acid water (HAW) showed virucidal activity against SARS-CoV-2.; Various HAW products showed virucidal activity regardless of manufacturing methods.; Virucidal activity of HAWs depends on the amount of residual chlorine (RC).; HAWs with pH 5.0–6.4 maintained high RC concentration for 21 days.; RC concentration was rapidly decreased in HAW with pH ≤ 3.0.;Yohei TakedaSachiko MatsudaDulamjav JamsransurenHaruko OgawaIWA Publishingarticledisinfectanthypochlorous acid watermanufacturing methodphsars-cov-2Public aspects of medicineRA1-1270ENJournal of Water and Health, Vol 19, Iss 3, Pp 448-456 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	disinfectant hypochlorous acid water manufacturing method ph sars-cov-2 Public aspects of medicine RA1-1270
spellingShingle	disinfectant hypochlorous acid water manufacturing method ph sars-cov-2 Public aspects of medicine RA1-1270 Yohei Takeda Sachiko Matsuda Dulamjav Jamsransuren Haruko Ogawa Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
description	The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. However, different manufacturing methods have produced several HAW products with various pH values. Here, we compared the SARS-CoV-2-inactivating activities of various HAW products. At sufficiently high volume and residual chlorine concentration (RCC), the HAW products inactivated SARS-CoV-2 efficiently regardless of pH or manufacturing method. However, although HAW products at pH 5.0–6.4 maintained high RCC and sustained virucidal activity for 21 days, the RCC rapidly decreased in HAW products at pH ≤ 3.0. Our results may guide in choosing appropriate HAW products for different usage situations. HIGHLIGHTS Hypochlorous acid water (HAW) showed virucidal activity against SARS-CoV-2.; Various HAW products showed virucidal activity regardless of manufacturing methods.; Virucidal activity of HAWs depends on the amount of residual chlorine (RC).; HAWs with pH 5.0–6.4 maintained high RC concentration for 21 days.; RC concentration was rapidly decreased in HAW with pH ≤ 3.0.;
format	article
author	Yohei Takeda Sachiko Matsuda Dulamjav Jamsransuren Haruko Ogawa
author_facet	Yohei Takeda Sachiko Matsuda Dulamjav Jamsransuren Haruko Ogawa
author_sort	Yohei Takeda
title	Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
title_short	Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
title_full	Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
title_fullStr	Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
title_full_unstemmed	Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH
title_sort	comparison of the sars-cov-2-inactivating activities of the differently manufactured hypochlorous acid water products with various ph
publisher	IWA Publishing
publishDate	2021
url	https://doaj.org/article/40e69f7527bd4edc88063dc2d3600cf8
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Comparison of the SARS-CoV-2-inactivating activities of the differently manufactured hypochlorous acid water products with various pH

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