Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.

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Bibliographic Details
Main Authors: Iwo Kucinski, Michael Dinan, Golnar Kolahgar, Eugenia Piddini
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Q
Online Access:https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c199
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Summary:Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.