Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.

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Autores principales:	Iwo Kucinski, Michael Dinan, Golnar Kolahgar, Eugenia Piddini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c199
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spelling	oai:doaj.org-article:40e708fdafc0405db4f51bc1e5a3c1992021-12-02T10:48:28ZChronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status10.1038/s41467-017-00145-y2041-1723https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c1992017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00145-yhttps://doaj.org/toc/2041-1723Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.Iwo KucinskiMichael DinanGolnar KolahgarEugenia PiddiniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
description	Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.
format	article
author	Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini
author_facet	Iwo Kucinski Michael Dinan Golnar Kolahgar Eugenia Piddini
author_sort	Iwo Kucinski
title	Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
title_short	Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
title_full	Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
title_fullStr	Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
title_full_unstemmed	Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status
title_sort	chronic activation of jnk jak/stat and oxidative stress signalling causes the loser cell status
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c199
work_keys_str_mv	AT iwokucinski chronicactivationofjnkjakstatandoxidativestresssignallingcausesthelosercellstatus AT michaeldinan chronicactivationofjnkjakstatandoxidativestresssignallingcausesthelosercellstatus AT golnarkolahgar chronicactivationofjnkjakstatandoxidativestresssignallingcausesthelosercellstatus AT eugeniapiddini chronicactivationofjnkjakstatandoxidativestresssignallingcausesthelosercellstatus
_version_	1718396642836611072

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status

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