A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.

Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalli...

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Autores principales:	Tim Hohm, Eckart Zitzler, Rüdiger Simon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40e79e25c74c4524942313a9b79a5547
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id	oai:doaj.org-article:40e79e25c74c4524942313a9b79a5547
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spelling	oai:doaj.org-article:40e79e25c74c4524942313a9b79a55472021-11-25T06:25:54ZA dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.1932-620310.1371/journal.pone.0009189https://doaj.org/article/40e79e25c74c4524942313a9b79a55472010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20169148/?tool=EBIhttps://doaj.org/toc/1932-6203Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalling between stem cells and surrounding cells. We have here simulated the origin and maintenance of a defined stem cell domain at the tip of Arabidopsis shoot meristems, based on the assumption that meristems are self-organizing systems. The model comprises two coupled feedback regulated genetic systems that control stem cell behaviour. Using a minimal set of spatial parameters, the mathematical model allows to predict the generation, shape and size of the stem cell domain, and the underlying organizing centre. We use the model to explore the parameter space that allows stem cell maintenance, and to simulate the consequences of mutations, gene misexpression and cell ablations.Tim HohmEckart ZitzlerRüdiger SimonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9189 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tim Hohm Eckart Zitzler Rüdiger Simon A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
description	Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life. Meristems are small groups of cells that provide the microenvironment that allows stem cells to prosper. Homeostasis of a stem cell domain within a growing meristem is achieved by signalling between stem cells and surrounding cells. We have here simulated the origin and maintenance of a defined stem cell domain at the tip of Arabidopsis shoot meristems, based on the assumption that meristems are self-organizing systems. The model comprises two coupled feedback regulated genetic systems that control stem cell behaviour. Using a minimal set of spatial parameters, the mathematical model allows to predict the generation, shape and size of the stem cell domain, and the underlying organizing centre. We use the model to explore the parameter space that allows stem cell maintenance, and to simulate the consequences of mutations, gene misexpression and cell ablations.
format	article
author	Tim Hohm Eckart Zitzler Rüdiger Simon
author_facet	Tim Hohm Eckart Zitzler Rüdiger Simon
author_sort	Tim Hohm
title	A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
title_short	A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
title_full	A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
title_fullStr	A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
title_full_unstemmed	A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.
title_sort	dynamic model for stem cell homeostasis and patterning in arabidopsis meristems.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/40e79e25c74c4524942313a9b79a5547
work_keys_str_mv	AT timhohm adynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems AT eckartzitzler adynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems AT rudigersimon adynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems AT timhohm dynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems AT eckartzitzler dynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems AT rudigersimon dynamicmodelforstemcellhomeostasisandpatterninginarabidopsismeristems
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A dynamic model for stem cell homeostasis and patterning in Arabidopsis meristems.

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