Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
Abstract In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-Co...
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Nature Portfolio
2021
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oai:doaj.org-article:40e8861416814771a3d5324fa7cd50bc2021-12-02T14:06:57ZDysregulation of lipid metabolism and pathological inflammation in patients with COVID-1910.1038/s41598-021-82426-72045-2322https://doaj.org/article/40e8861416814771a3d5324fa7cd50bc2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82426-7https://doaj.org/toc/2045-2322Abstract In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets.Marianna CaterinoMonica GelzoStefano SolRoberta FedeleAnna AnnunziataCecilia CalabreseGiuseppe FiorentinoMaurizio D’AbbraccioChiara Dell’IsolaFrancesco Maria FuscoRoberto ParrellaGabriella FabbrociniIvan GentileImmacolata AndolfoMario CapassoMichele CostanzoAurora DanieleEmanuela MarcheseRita PolitoRoberta RussoCaterina MisseroMargherita RuoppoloGiuseppe CastaldoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Marianna Caterino Monica Gelzo Stefano Sol Roberta Fedele Anna Annunziata Cecilia Calabrese Giuseppe Fiorentino Maurizio D’Abbraccio Chiara Dell’Isola Francesco Maria Fusco Roberto Parrella Gabriella Fabbrocini Ivan Gentile Immacolata Andolfo Mario Capasso Michele Costanzo Aurora Daniele Emanuela Marchese Rita Polito Roberta Russo Caterina Missero Margherita Ruoppolo Giuseppe Castaldo Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| description |
Abstract In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infections, pathogenesis and progression have not been clearly elucidated yet, thus forcing the development of many complementary approaches to identify candidate cellular pathways involved in disease progression. Host lipids play a critical role in the virus life, being the double-membrane vesicles a key factor in coronavirus replication. Moreover, lipid biogenesis pathways affect receptor-mediated virus entry at the endosomal cell surface and modulate virus propagation. In this study, targeted lipidomic analysis coupled with proinflammatory cytokines and alarmins measurement were carried out in serum of COVID-19 patients characterized by different severity degree. Serum IL-26, a cytokine involved in IL-17 pathway, TSLP and adiponectin were measured and correlated to lipid COVID-19 patient profiles. These results could be important for the classification of the COVID-19 disease and the identification of therapeutic targets. |
| format |
article |
| author |
Marianna Caterino Monica Gelzo Stefano Sol Roberta Fedele Anna Annunziata Cecilia Calabrese Giuseppe Fiorentino Maurizio D’Abbraccio Chiara Dell’Isola Francesco Maria Fusco Roberto Parrella Gabriella Fabbrocini Ivan Gentile Immacolata Andolfo Mario Capasso Michele Costanzo Aurora Daniele Emanuela Marchese Rita Polito Roberta Russo Caterina Missero Margherita Ruoppolo Giuseppe Castaldo |
| author_facet |
Marianna Caterino Monica Gelzo Stefano Sol Roberta Fedele Anna Annunziata Cecilia Calabrese Giuseppe Fiorentino Maurizio D’Abbraccio Chiara Dell’Isola Francesco Maria Fusco Roberto Parrella Gabriella Fabbrocini Ivan Gentile Immacolata Andolfo Mario Capasso Michele Costanzo Aurora Daniele Emanuela Marchese Rita Polito Roberta Russo Caterina Missero Margherita Ruoppolo Giuseppe Castaldo |
| author_sort |
Marianna Caterino |
| title |
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| title_short |
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| title_full |
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| title_fullStr |
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| title_full_unstemmed |
Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19 |
| title_sort |
dysregulation of lipid metabolism and pathological inflammation in patients with covid-19 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/40e8861416814771a3d5324fa7cd50bc |
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