Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.

<h4>Objective</h4>To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care.<h4>Methods</h4>A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any...

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Autores principales:	Nalinee Poolsup, Naeti Suksomboon, Muhammad Amin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40ea8b9ce6664758ae0734a007cc4323
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spelling	oai:doaj.org-article:40ea8b9ce6664758ae0734a007cc43232021-11-18T08:26:50ZEffect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0092485https://doaj.org/article/40ea8b9ce6664758ae0734a007cc43232014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24658089/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care.<h4>Methods</h4>A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any form of therapeutic intervention in comparison to usual antenatal care. A literature search was conducted using electronic databases together with a hand search of relevant journals and conference proceedings.<h4>Results</h4>Ten studies involving 3,881 patients contributed to meta-analysis. Our results indicated that gestational diabetes mellitus treatment significantly reduced the risk for macrosomia (RR, 0.47; 95% CI, 0.38-0.57), large for gestational age births (RR, 0.55; 95% CI, 0.45-0.67), shoulder dystocia (RR, 0.42; 95% CI, 0.23-0.77) and gestational hypertension (RR, 0.68; 95% CI, 0.53-0.87) without causing any significant increase in the risk for small for gestational age babies. However, no significant difference was observed between the two groups regarding perinatal/neonatal mortality, neonatal hypoglycemia, birth trauma, preterm births, pre-eclampsia, caesarean section and labor induction.<h4>Conclusion</h4>Treating GDM reduces risk for many important adverse pregnancy outcomes and its association with any harm seems unlikely.Nalinee PoolsupNaeti SuksomboonMuhammad AminPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e92485 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nalinee Poolsup Naeti Suksomboon Muhammad Amin Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
description	<h4>Objective</h4>To assess the efficacy and safety of treating pregnant women with gestational diabetes mellitus in comparison to usual antenatal care.<h4>Methods</h4>A systematic review and meta-analysis was conducted by including randomized controlled trials comparing any form of therapeutic intervention in comparison to usual antenatal care. A literature search was conducted using electronic databases together with a hand search of relevant journals and conference proceedings.<h4>Results</h4>Ten studies involving 3,881 patients contributed to meta-analysis. Our results indicated that gestational diabetes mellitus treatment significantly reduced the risk for macrosomia (RR, 0.47; 95% CI, 0.38-0.57), large for gestational age births (RR, 0.55; 95% CI, 0.45-0.67), shoulder dystocia (RR, 0.42; 95% CI, 0.23-0.77) and gestational hypertension (RR, 0.68; 95% CI, 0.53-0.87) without causing any significant increase in the risk for small for gestational age babies. However, no significant difference was observed between the two groups regarding perinatal/neonatal mortality, neonatal hypoglycemia, birth trauma, preterm births, pre-eclampsia, caesarean section and labor induction.<h4>Conclusion</h4>Treating GDM reduces risk for many important adverse pregnancy outcomes and its association with any harm seems unlikely.
format	article
author	Nalinee Poolsup Naeti Suksomboon Muhammad Amin
author_facet	Nalinee Poolsup Naeti Suksomboon Muhammad Amin
author_sort	Nalinee Poolsup
title	Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
title_short	Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
title_full	Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
title_fullStr	Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
title_full_unstemmed	Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
title_sort	effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/40ea8b9ce6664758ae0734a007cc4323
work_keys_str_mv	AT nalineepoolsup effectoftreatmentofgestationaldiabetesmellitusasystematicreviewandmetaanalysis AT naetisuksomboon effectoftreatmentofgestationaldiabetesmellitusasystematicreviewandmetaanalysis AT muhammadamin effectoftreatmentofgestationaldiabetesmellitusasystematicreviewandmetaanalysis
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Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis.

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