Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.

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Autores principales: Brandon L. Pearson, Jeremy M. Simon, Eric S. McCoy, Gabriela Salazar, Giulia Fragola, Mark J. Zylka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
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spelling oai:doaj.org-article:40eab20cb9c14472bd55674dbc22b4f92021-12-02T17:32:22ZIdentification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration10.1038/ncomms111732041-1723https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f92016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11173https://doaj.org/toc/2041-1723This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.Brandon L. PearsonJeremy M. SimonEric S. McCoyGabriela SalazarGiulia FragolaMark J. ZylkaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Brandon L. Pearson
Jeremy M. Simon
Eric S. McCoy
Gabriela Salazar
Giulia Fragola
Mark J. Zylka
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
description This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.
format article
author Brandon L. Pearson
Jeremy M. Simon
Eric S. McCoy
Gabriela Salazar
Giulia Fragola
Mark J. Zylka
author_facet Brandon L. Pearson
Jeremy M. Simon
Eric S. McCoy
Gabriela Salazar
Giulia Fragola
Mark J. Zylka
author_sort Brandon L. Pearson
title Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_short Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_full Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_fullStr Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_full_unstemmed Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_sort identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
work_keys_str_mv AT brandonlpearson identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration
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AT gabrielasalazar identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration
AT giuliafragola identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration
AT markjzylka identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration
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