Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.

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Bibliographic Details
Main Authors:	Brandon L. Pearson, Jeremy M. Simon, Eric S. McCoy, Gabriela Salazar, Giulia Fragola, Mark J. Zylka
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
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spelling	oai:doaj.org-article:40eab20cb9c14472bd55674dbc22b4f92021-12-02T17:32:22ZIdentification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration10.1038/ncomms111732041-1723https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f92016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11173https://doaj.org/toc/2041-1723This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.Brandon L. PearsonJeremy M. SimonEric S. McCoyGabriela SalazarGiulia FragolaMark J. ZylkaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
description	This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.
format	article
author	Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka
author_facet	Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka
author_sort	Brandon L. Pearson
title	Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_short	Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_full	Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_fullStr	Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_full_unstemmed	Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
title_sort	identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
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Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration

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