Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration
This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.
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Nature Portfolio
2016
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oai:doaj.org-article:40eab20cb9c14472bd55674dbc22b4f92021-12-02T17:32:22ZIdentification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration10.1038/ncomms111732041-1723https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f92016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11173https://doaj.org/toc/2041-1723This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration.Brandon L. PearsonJeremy M. SimonEric S. McCoyGabriela SalazarGiulia FragolaMark J. ZylkaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
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Science Q |
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Science Q Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
description |
This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected with autism, aging, and neurodegeneration. |
format |
article |
author |
Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka |
author_facet |
Brandon L. Pearson Jeremy M. Simon Eric S. McCoy Gabriela Salazar Giulia Fragola Mark J. Zylka |
author_sort |
Brandon L. Pearson |
title |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
title_short |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
title_full |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
title_fullStr |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
title_full_unstemmed |
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
title_sort |
identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9 |
work_keys_str_mv |
AT brandonlpearson identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration AT jeremymsimon identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration AT ericsmccoy identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration AT gabrielasalazar identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration AT giuliafragola identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration AT markjzylka identificationofchemicalsthatmimictranscriptionalchangesassociatedwithautismbrainagingandneurodegeneration |
_version_ |
1718380305846370304 |