TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis.

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Autores principales:	Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang, Peng Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40ebfb1c694843deb3649bc0de6df26d
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spelling	oai:doaj.org-article:40ebfb1c694843deb3649bc0de6df26d2021-12-02T17:32:01ZTAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation10.1038/s41467-018-07127-82041-1723https://doaj.org/article/40ebfb1c694843deb3649bc0de6df26d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07127-8https://doaj.org/toc/2041-1723TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis.Le LiLijia LiWei LiTaiqi ChenBin ZouLina ZhaoHuili WangXueying WangLina XuXiaohui LiuDong WangBo LiTak W. MakWenjing DuXiaolu YangPeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Le Li Lijia Li Wei Li Taiqi Chen Bin Zou Lina Zhao Huili Wang Xueying Wang Lina Xu Xiaohui Liu Dong Wang Bo Li Tak W. Mak Wenjing Du Xiaolu Yang Peng Jiang TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
description	TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis.
format	article
author	Le Li Lijia Li Wei Li Taiqi Chen Bin Zou Lina Zhao Huili Wang Xueying Wang Lina Xu Xiaohui Liu Dong Wang Bo Li Tak W. Mak Wenjing Du Xiaolu Yang Peng Jiang
author_facet	Le Li Lijia Li Wei Li Taiqi Chen Bin Zou Lina Zhao Huili Wang Xueying Wang Lina Xu Xiaohui Liu Dong Wang Bo Li Tak W. Mak Wenjing Du Xiaolu Yang Peng Jiang
author_sort	Le Li
title	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
title_short	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
title_full	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
title_fullStr	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
title_full_unstemmed	TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
title_sort	tap73-induced phosphofructokinase-1 transcription promotes the warburg effect and enhances cell proliferation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/40ebfb1c694843deb3649bc0de6df26d
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TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

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