Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy

Abstract We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concent...

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Autores principales:	Dan Wang, Yu Zhang, Juan Han, Xiao Li, Xiaofeng Chen, Tianzhu Qiu, Hua Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40ed36667c654213b27aab2885b903fd
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spelling	oai:doaj.org-article:40ed36667c654213b27aab2885b903fd2021-12-02T17:45:03ZQuantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy10.1038/s41598-021-92656-42045-2322https://doaj.org/article/40ed36667c654213b27aab2885b903fd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92656-4https://doaj.org/toc/2045-2322Abstract We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice.Dan WangYu ZhangJuan HanXiao LiXiaofeng ChenTianzhu QiuHua ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dan Wang Yu Zhang Juan Han Xiao Li Xiaofeng Chen Tianzhu Qiu Hua Chen Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
description	Abstract We conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice.
format	article
author	Dan Wang Yu Zhang Juan Han Xiao Li Xiaofeng Chen Tianzhu Qiu Hua Chen
author_facet	Dan Wang Yu Zhang Juan Han Xiao Li Xiaofeng Chen Tianzhu Qiu Hua Chen
author_sort	Dan Wang
title	Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_short	Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_full	Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_fullStr	Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_full_unstemmed	Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
title_sort	quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40ed36667c654213b27aab2885b903fd
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Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy

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