Selective protection of human liver tissue in TNF-targeting of cancers of the liver by transient depletion of adenosine triphosphate.

Selective protection of human liver tissue in TNF-targeting of cancers of the liver by transient depletion of adenosine triphosphate.

<h4>Background</h4>Tumor necrosis factor alpha (TNF) is able to kill cancer cells via receptor-mediated cell death requiring adenosine triphosphate (ATP). Clinical usage of TNF so far is largely limited by its profound hepatotoxicity. Recently, it was found in the murine system that spec...

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Main Authors: Timo Weiland, Kathrin Klein, Martina Zimmermann, Tobias Speicher, Sascha Venturelli, Alexander Berger, Heike Bantel, Alfred Königsrainer, Martin Schenk, Thomas S Weiss, Albrecht Wendel, Matthias Schwab, Michael Bitzer, Ulrich M Lauer
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/40f27c78dffb47319a381d20a5dde9ae
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