Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection

Abstract Despite great advances in describing Bordetella pertussis infection, the role of the host microbiota in pertussis pathogenesis remains unexplored. Indeed, the microbiota plays important role in defending against bacterial and viral respiratory infections. We investigated the nasopharyngeal...

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Autores principales:	A. E. Tozzi, F. Del Chierico, E. Pandolfi, S. Reddel, F. Gesualdo, S. Gardini, V. Guarrasi, L. Russo, I. Croci, I. Campagna, G. Linardos, C. Concato, A. Villani, L. Putignani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40f3ca018ddc4730b2b5d474c6db10b2
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spelling	oai:doaj.org-article:40f3ca018ddc4730b2b5d474c6db10b22021-11-28T12:18:08ZNasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection10.1038/s41598-021-02322-y2045-2322https://doaj.org/article/40f3ca018ddc4730b2b5d474c6db10b22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02322-yhttps://doaj.org/toc/2045-2322Abstract Despite great advances in describing Bordetella pertussis infection, the role of the host microbiota in pertussis pathogenesis remains unexplored. Indeed, the microbiota plays important role in defending against bacterial and viral respiratory infections. We investigated the nasopharyngeal microbiota in infants infected by B. pertussis (Bp), Rhinovirus (Rv) and simultaneously by both infectious agents (Bp + Rv). We demonstrated a specific nasopharyngeal microbiome profiles for Bp group, compared to Rv and Bp + Rv groups, and a reduction of microbial richness during coinfection compared to the single infections. The comparison amongst the three groups showed the increase of Alcaligenaceae and Achromobacter in Bp and Moraxellaceae and Moraxella in Rv group. Furthermore, correlation analysis between patients’ features and nasopharyngeal microbiota profile highlighted a link between delivery and feeding modality, antibiotic administration and B. pertussis infection. A model classification demonstrated a microbiota fingerprinting specific of Bp and Rv infections. In conclusion, external factors since the first moments of life contribute to the alteration of nasopharyngeal microbiota, indeed increasing the susceptibility of the host to the pathogens' infections. When the infection is triggered, the presence of infectious agents modifies the microbiota favoring the overgrowth of commensal bacteria that turn in pathobionts, hence contributing to the disease severity.A. E. TozziF. Del ChiericoE. PandolfiS. ReddelF. GesualdoS. GardiniV. GuarrasiL. RussoI. CrociI. CampagnaG. LinardosC. ConcatoA. VillaniL. PutignaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. E. Tozzi F. Del Chierico E. Pandolfi S. Reddel F. Gesualdo S. Gardini V. Guarrasi L. Russo I. Croci I. Campagna G. Linardos C. Concato A. Villani L. Putignani Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
description	Abstract Despite great advances in describing Bordetella pertussis infection, the role of the host microbiota in pertussis pathogenesis remains unexplored. Indeed, the microbiota plays important role in defending against bacterial and viral respiratory infections. We investigated the nasopharyngeal microbiota in infants infected by B. pertussis (Bp), Rhinovirus (Rv) and simultaneously by both infectious agents (Bp + Rv). We demonstrated a specific nasopharyngeal microbiome profiles for Bp group, compared to Rv and Bp + Rv groups, and a reduction of microbial richness during coinfection compared to the single infections. The comparison amongst the three groups showed the increase of Alcaligenaceae and Achromobacter in Bp and Moraxellaceae and Moraxella in Rv group. Furthermore, correlation analysis between patients’ features and nasopharyngeal microbiota profile highlighted a link between delivery and feeding modality, antibiotic administration and B. pertussis infection. A model classification demonstrated a microbiota fingerprinting specific of Bp and Rv infections. In conclusion, external factors since the first moments of life contribute to the alteration of nasopharyngeal microbiota, indeed increasing the susceptibility of the host to the pathogens' infections. When the infection is triggered, the presence of infectious agents modifies the microbiota favoring the overgrowth of commensal bacteria that turn in pathobionts, hence contributing to the disease severity.
format	article
author	A. E. Tozzi F. Del Chierico E. Pandolfi S. Reddel F. Gesualdo S. Gardini V. Guarrasi L. Russo I. Croci I. Campagna G. Linardos C. Concato A. Villani L. Putignani
author_facet	A. E. Tozzi F. Del Chierico E. Pandolfi S. Reddel F. Gesualdo S. Gardini V. Guarrasi L. Russo I. Croci I. Campagna G. Linardos C. Concato A. Villani L. Putignani
author_sort	A. E. Tozzi
title	Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
title_short	Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
title_full	Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
title_fullStr	Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
title_full_unstemmed	Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection
title_sort	nasopharyngeal microbiota in hospitalized children with bordetella pertussis and rhinovirus infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40f3ca018ddc4730b2b5d474c6db10b2
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Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection

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