Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production

Innate immunity is the front-line defense against infectious microorganisms, including viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral, antiproliferative, and immunomodulatory functions in cells. The cGAS–STING pathway, comprising the main DNA sensor cyclic...

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Autores principales:	Kunli Zhang, Sutian Wang, Hongchao Gou, Jianfeng Zhang, Chunling Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autophagy CGAS STING type I IFNs production signalling pathway Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/40f688747aae4b79a0c774ae28f4fb59
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spelling	oai:doaj.org-article:40f688747aae4b79a0c774ae28f4fb592021-12-03T09:02:57ZCrosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production2296-634X10.3389/fcell.2021.748485https://doaj.org/article/40f688747aae4b79a0c774ae28f4fb592021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.748485/fullhttps://doaj.org/toc/2296-634XInnate immunity is the front-line defense against infectious microorganisms, including viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral, antiproliferative, and immunomodulatory functions in cells. The cGAS–STING pathway, comprising the main DNA sensor cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS) and stimulator of IFN genes (STING), is a major pathway that mediates immune reactions and is involved in the strong induction of type I IFN production, which can fight against microbial infections. Autophagy is an evolutionarily conserved degradation process that is required to maintain host health and facilitate capture and elimination of invading pathogens by the immune system. Mounting evidence indicates that autophagy plays an important role in cGAS–STING signaling pathway-mediated type I IFN production. This review briefly summarizes the research progress on how autophagy regulates the cGAS–STING pathway, regulating type I IFN production, with a particular focus on the crosstalk between autophagy and cGAS–STING signaling during infection by pathogenic microorganisms.Kunli ZhangSutian WangHongchao GouJianfeng ZhangJianfeng ZhangChunling LiFrontiers Media S.A.articleautophagyCGASSTINGtype I IFNs productionsignalling pathwayBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autophagy CGAS STING type I IFNs production signalling pathway Biology (General) QH301-705.5
spellingShingle	autophagy CGAS STING type I IFNs production signalling pathway Biology (General) QH301-705.5 Kunli Zhang Sutian Wang Hongchao Gou Jianfeng Zhang Jianfeng Zhang Chunling Li Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
description	Innate immunity is the front-line defense against infectious microorganisms, including viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral, antiproliferative, and immunomodulatory functions in cells. The cGAS–STING pathway, comprising the main DNA sensor cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS) and stimulator of IFN genes (STING), is a major pathway that mediates immune reactions and is involved in the strong induction of type I IFN production, which can fight against microbial infections. Autophagy is an evolutionarily conserved degradation process that is required to maintain host health and facilitate capture and elimination of invading pathogens by the immune system. Mounting evidence indicates that autophagy plays an important role in cGAS–STING signaling pathway-mediated type I IFN production. This review briefly summarizes the research progress on how autophagy regulates the cGAS–STING pathway, regulating type I IFN production, with a particular focus on the crosstalk between autophagy and cGAS–STING signaling during infection by pathogenic microorganisms.
format	article
author	Kunli Zhang Sutian Wang Hongchao Gou Jianfeng Zhang Jianfeng Zhang Chunling Li
author_facet	Kunli Zhang Sutian Wang Hongchao Gou Jianfeng Zhang Jianfeng Zhang Chunling Li
author_sort	Kunli Zhang
title	Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
title_short	Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
title_full	Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
title_fullStr	Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
title_full_unstemmed	Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
title_sort	crosstalk between autophagy and the cgas–sting signaling pathway in type i interferon production
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/40f688747aae4b79a0c774ae28f4fb59
work_keys_str_mv	AT kunlizhang crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction AT sutianwang crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction AT hongchaogou crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction AT jianfengzhang crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction AT jianfengzhang crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction AT chunlingli crosstalkbetweenautophagyandthecgasstingsignalingpathwayintypeiinterferonproduction
_version_	1718373383261913088

Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production

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