Serum zinc levels and in vivo beta-amyloid deposition in the human brain

Abstract Background Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid prot...

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Autores principales:	Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Min Jung Kim, Gijung Jung, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee, for the KBASE Research Group
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Zinc Aβ Alzheimer’s disease APOE4 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/40faa8b565bd416bbf8628dab1fcc9a1
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spelling	oai:doaj.org-article:40faa8b565bd416bbf8628dab1fcc9a12021-11-21T12:40:25ZSerum zinc levels and in vivo beta-amyloid deposition in the human brain10.1186/s13195-021-00931-31758-9193https://doaj.org/article/40faa8b565bd416bbf8628dab1fcc9a12021-11-01T00:00:00Zhttps://doi.org/10.1186/s13195-021-00931-3https://doaj.org/toc/1758-9193Abstract Background Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Aβ) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 μg/dL (low), 80 to 90 μg/dL (medium), and > 90 μg/dL (high). Results A low serum zinc level was significantly associated with increased Aβ retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Aβ retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.Jee Wook KimMin Soo ByunDahyun YiJun Ho LeeMin Jung KimGijung JungJun-Young LeeKoung Mi KangChul-Ho SohnYun-Sang LeeYu Kyeong KimDong Young Leefor the KBASE Research GroupBMCarticleZincAβAlzheimer’s diseaseAPOE4Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAlzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zinc Aβ Alzheimer’s disease APOE4 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Zinc Aβ Alzheimer’s disease APOE4 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jee Wook Kim Min Soo Byun Dahyun Yi Jun Ho Lee Min Jung Kim Gijung Jung Jun-Young Lee Koung Mi Kang Chul-Ho Sohn Yun-Sang Lee Yu Kyeong Kim Dong Young Lee for the KBASE Research Group Serum zinc levels and in vivo beta-amyloid deposition in the human brain
description	Abstract Background Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Aβ) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 μg/dL (low), 80 to 90 μg/dL (medium), and > 90 μg/dL (high). Results A low serum zinc level was significantly associated with increased Aβ retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Aβ retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.
format	article
author	Jee Wook Kim Min Soo Byun Dahyun Yi Jun Ho Lee Min Jung Kim Gijung Jung Jun-Young Lee Koung Mi Kang Chul-Ho Sohn Yun-Sang Lee Yu Kyeong Kim Dong Young Lee for the KBASE Research Group
author_facet	Jee Wook Kim Min Soo Byun Dahyun Yi Jun Ho Lee Min Jung Kim Gijung Jung Jun-Young Lee Koung Mi Kang Chul-Ho Sohn Yun-Sang Lee Yu Kyeong Kim Dong Young Lee for the KBASE Research Group
author_sort	Jee Wook Kim
title	Serum zinc levels and in vivo beta-amyloid deposition in the human brain
title_short	Serum zinc levels and in vivo beta-amyloid deposition in the human brain
title_full	Serum zinc levels and in vivo beta-amyloid deposition in the human brain
title_fullStr	Serum zinc levels and in vivo beta-amyloid deposition in the human brain
title_full_unstemmed	Serum zinc levels and in vivo beta-amyloid deposition in the human brain
title_sort	serum zinc levels and in vivo beta-amyloid deposition in the human brain
publisher	BMC
publishDate	2021
url	https://doaj.org/article/40faa8b565bd416bbf8628dab1fcc9a1
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Serum zinc levels and in vivo beta-amyloid deposition in the human brain

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