Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.

Particulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was develop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laura C Palacio, Diana C Pachajoa, Geraldine Durango-Giraldo, Camilo Zapata-Hernandez, Juan P Ugarte, Javier Saiz, Robison Buitrago-Sierra, Catalina Tobón
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40fbc7ed48d04be28679228a4714672e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:40fbc7ed48d04be28679228a4714672e
record_format	dspace
spelling	oai:doaj.org-article:40fbc7ed48d04be28679228a4714672e2021-12-02T20:13:44ZAtrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.1932-620310.1371/journal.pone.0258313https://doaj.org/article/40fbc7ed48d04be28679228a4714672e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258313https://doaj.org/toc/1932-6203Particulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was developed. The results evince that lead (Pb) is one of the most abundant elements since it is present in all analyzed samples. Therefore, Pb was chosen to perform an in-silico study to assess its effects on atrial arrhythmias generation. For this purpose, we developed a model representing the Pb2+ blocking effect on the L-type calcium channel. This formulation was incorporated in a human atrial cell mathematical model and in 2D and 3D models of human atria. The simulations showed a proarrhythmic effect at high Pb2+ concentrations, through shortening of action potential duration inducing the generation of reentrant activity and atrial flutter. The results contribute to the knowledge about the cardiac physiopathological processes, triggered by lead as one of the main PM10 metal components of air pollution, that yields the generation of arrhythmias.Laura C PalacioDiana C PachajoaGeraldine Durango-GiraldoCamilo Zapata-HernandezJuan P UgarteJavier SaizRobison Buitrago-SierraCatalina TobónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258313 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura C Palacio Diana C Pachajoa Geraldine Durango-Giraldo Camilo Zapata-Hernandez Juan P Ugarte Javier Saiz Robison Buitrago-Sierra Catalina Tobón Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
description	Particulate matter (PM) is considered the most severe environmental pollution problem due to its serious effects on human health associated with an increased risk of cardiovascular morbidity and mortality. In this work, a physicochemical characterization of PM10 from the city of Medellin was developed. The results evince that lead (Pb) is one of the most abundant elements since it is present in all analyzed samples. Therefore, Pb was chosen to perform an in-silico study to assess its effects on atrial arrhythmias generation. For this purpose, we developed a model representing the Pb2+ blocking effect on the L-type calcium channel. This formulation was incorporated in a human atrial cell mathematical model and in 2D and 3D models of human atria. The simulations showed a proarrhythmic effect at high Pb2+ concentrations, through shortening of action potential duration inducing the generation of reentrant activity and atrial flutter. The results contribute to the knowledge about the cardiac physiopathological processes, triggered by lead as one of the main PM10 metal components of air pollution, that yields the generation of arrhythmias.
format	article
author	Laura C Palacio Diana C Pachajoa Geraldine Durango-Giraldo Camilo Zapata-Hernandez Juan P Ugarte Javier Saiz Robison Buitrago-Sierra Catalina Tobón
author_facet	Laura C Palacio Diana C Pachajoa Geraldine Durango-Giraldo Camilo Zapata-Hernandez Juan P Ugarte Javier Saiz Robison Buitrago-Sierra Catalina Tobón
author_sort	Laura C Palacio
title	Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
title_short	Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
title_full	Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
title_fullStr	Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
title_full_unstemmed	Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.
title_sort	atrial proarrhythmic effect of lead as one of the pm10 metal components of air pollution. an in-silico study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/40fbc7ed48d04be28679228a4714672e
work_keys_str_mv	AT lauracpalacio atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT dianacpachajoa atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT geraldinedurangogiraldo atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT camilozapatahernandez atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT juanpugarte atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT javiersaiz atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT robisonbuitragosierra atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy AT catalinatobon atrialproarrhythmiceffectofleadasoneofthepm10metalcomponentsofairpollutionaninsilicostudy
_version_	1718374699411439616

Atrial proarrhythmic effect of lead as one of the PM10 metal components of air pollution. An in-silico study.

Ejemplares similares