Gadd45g is essential for primary sex determination, male fertility and testis development.
In humans and most mammals, differentiation of the embryonic gonad into ovaries or testes is controlled by the Y-linked gene SRY. Here we show a role for the Gadd45g protein in this primary sex differentiation. We characterized mice deficient in Gadd45a, Gadd45b and Gadd45g, as well as double-knocko...
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Autores principales: | Heiko Johnen, Laura González-Silva, Laura Carramolino, Juana Maria Flores, Miguel Torres, Jesús M Salvador |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/40fd70142290441095bfda1c7d631b41 |
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