Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA

Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.

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Autores principales:	Ei-Wen Yang, Jae Hoon Bahn, Esther Yun-Hua Hsiao, Boon Xin Tan, Yiwei Sun, Ting Fu, Bo Zhou, Eric L. Van Nostrand, Gabriel A. Pratt, Peter Freese, Xintao Wei, Giovanni Quinones-Valdez, Alexander E. Urban, Brenton R. Graveley, Christopher B. Burge, Gene W. Yeo, Xinshu Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40fe4f1d191643449b3e71a16d4eeda4
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spelling	oai:doaj.org-article:40fe4f1d191643449b3e71a16d4eeda42021-12-02T17:01:27ZAllele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA10.1038/s41467-019-09292-w2041-1723https://doaj.org/article/40fe4f1d191643449b3e71a16d4eeda42019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09292-whttps://doaj.org/toc/2041-1723Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.Ei-Wen YangJae Hoon BahnEsther Yun-Hua HsiaoBoon Xin TanYiwei SunTing FuBo ZhouEric L. Van NostrandGabriel A. PrattPeter FreeseXintao WeiGiovanni Quinones-ValdezAlexander E. UrbanBrenton R. GraveleyChristopher B. BurgeGene W. YeoXinshu XiaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ei-Wen Yang Jae Hoon Bahn Esther Yun-Hua Hsiao Boon Xin Tan Yiwei Sun Ting Fu Bo Zhou Eric L. Van Nostrand Gabriel A. Pratt Peter Freese Xintao Wei Giovanni Quinones-Valdez Alexander E. Urban Brenton R. Graveley Christopher B. Burge Gene W. Yeo Xinshu Xiao Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
description	Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.
format	article
author	Ei-Wen Yang Jae Hoon Bahn Esther Yun-Hua Hsiao Boon Xin Tan Yiwei Sun Ting Fu Bo Zhou Eric L. Van Nostrand Gabriel A. Pratt Peter Freese Xintao Wei Giovanni Quinones-Valdez Alexander E. Urban Brenton R. Graveley Christopher B. Burge Gene W. Yeo Xinshu Xiao
author_facet	Ei-Wen Yang Jae Hoon Bahn Esther Yun-Hua Hsiao Boon Xin Tan Yiwei Sun Ting Fu Bo Zhou Eric L. Van Nostrand Gabriel A. Pratt Peter Freese Xintao Wei Giovanni Quinones-Valdez Alexander E. Urban Brenton R. Graveley Christopher B. Burge Gene W. Yeo Xinshu Xiao
author_sort	Ei-Wen Yang
title	Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
title_short	Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
title_full	Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
title_fullStr	Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
title_full_unstemmed	Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
title_sort	allele-specific binding of rna-binding proteins reveals functional genetic variants in the rna
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/40fe4f1d191643449b3e71a16d4eeda4
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Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA

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