Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

Natural killer homeostasis is thought to be governed by gamma chain cytokines including IL-15. Here, the authors show that IL-12 can trigger the development of a distinct subset of natural killer cells with anti-tumour activity.

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Autores principales:	Isabel Ohs, Maries van den Broek, Kathrin Nussbaum, Christian Münz, Sebastian J. Arnold, Sergio A. Quezada, Sonia Tugues, Burkhard Becher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40fe5d23c28e4aabb9c6dedf9ca40c55
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spelling	oai:doaj.org-article:40fe5d23c28e4aabb9c6dedf9ca40c552021-12-02T15:34:54ZInterleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis10.1038/ncomms137082041-1723https://doaj.org/article/40fe5d23c28e4aabb9c6dedf9ca40c552016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13708https://doaj.org/toc/2041-1723Natural killer homeostasis is thought to be governed by gamma chain cytokines including IL-15. Here, the authors show that IL-12 can trigger the development of a distinct subset of natural killer cells with anti-tumour activity.Isabel OhsMaries van den BroekKathrin NussbaumChristian MünzSebastian J. ArnoldSergio A. QuezadaSonia TuguesBurkhard BecherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabel Ohs Maries van den Broek Kathrin Nussbaum Christian Münz Sebastian J. Arnold Sergio A. Quezada Sonia Tugues Burkhard Becher Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
description	Natural killer homeostasis is thought to be governed by gamma chain cytokines including IL-15. Here, the authors show that IL-12 can trigger the development of a distinct subset of natural killer cells with anti-tumour activity.
format	article
author	Isabel Ohs Maries van den Broek Kathrin Nussbaum Christian Münz Sebastian J. Arnold Sergio A. Quezada Sonia Tugues Burkhard Becher
author_facet	Isabel Ohs Maries van den Broek Kathrin Nussbaum Christian Münz Sebastian J. Arnold Sergio A. Quezada Sonia Tugues Burkhard Becher
author_sort	Isabel Ohs
title	Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
title_short	Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
title_full	Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
title_fullStr	Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
title_full_unstemmed	Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
title_sort	interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/40fe5d23c28e4aabb9c6dedf9ca40c55
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Interleukin-12 bypasses common gamma-chain signalling in emergency natural killer cell lymphopoiesis

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