Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid
2,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway inE. coliby engineering enzymes from malate metabolism.
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Nature Portfolio
2017
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oai:doaj.org-article:40ffedfba15045e1b9289f7018cf93372021-12-02T15:38:51ZConstruction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid10.1038/ncomms158282041-1723https://doaj.org/article/40ffedfba15045e1b9289f7018cf93372017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15828https://doaj.org/toc/2041-17232,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway inE. coliby engineering enzymes from malate metabolism.Thomas WaltherChristopher M. TophamRomain IragueClément AuriolAudrey BaylacHélène CordierClémentine DressaireLuce Lozano-HuguetNathalie TarratNelly MartineauMarion StodelYannick MalbertMarc MaestracciRobert HuetIsabelle AndréMagali Remaud-SiméonJean Marie FrançoisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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| topic |
Science Q |
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Science Q Thomas Walther Christopher M. Topham Romain Irague Clément Auriol Audrey Baylac Hélène Cordier Clémentine Dressaire Luce Lozano-Huguet Nathalie Tarrat Nelly Martineau Marion Stodel Yannick Malbert Marc Maestracci Robert Huet Isabelle André Magali Remaud-Siméon Jean Marie François Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| description |
2,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway inE. coliby engineering enzymes from malate metabolism. |
| format |
article |
| author |
Thomas Walther Christopher M. Topham Romain Irague Clément Auriol Audrey Baylac Hélène Cordier Clémentine Dressaire Luce Lozano-Huguet Nathalie Tarrat Nelly Martineau Marion Stodel Yannick Malbert Marc Maestracci Robert Huet Isabelle André Magali Remaud-Siméon Jean Marie François |
| author_facet |
Thomas Walther Christopher M. Topham Romain Irague Clément Auriol Audrey Baylac Hélène Cordier Clémentine Dressaire Luce Lozano-Huguet Nathalie Tarrat Nelly Martineau Marion Stodel Yannick Malbert Marc Maestracci Robert Huet Isabelle André Magali Remaud-Siméon Jean Marie François |
| author_sort |
Thomas Walther |
| title |
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| title_short |
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| title_full |
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| title_fullStr |
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| title_full_unstemmed |
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| title_sort |
construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/40ffedfba15045e1b9289f7018cf9337 |
| work_keys_str_mv |
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