Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which le...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Renan V. H. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, Tamara S. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, Fabiani G. Frantz, Lucas B. Lorenzon, Marcos Michel Souza, Fausto Almeida, Lilian M. Cantanhêde, Ricardo de Godoi M. Ferreira, Angela K. Cruz, Dario S. Zamboni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/41009faa319b4c89b800738bd6213733
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which leads to autophagy-mediated NLRP3 degradation.

Ejemplares similares