Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which le...

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Autores principales:	Renan V. H. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, Tamara S. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, Fabiani G. Frantz, Lucas B. Lorenzon, Marcos Michel Souza, Fausto Almeida, Lilian M. Cantanhêde, Ricardo de Godoi M. Ferreira, Angela K. Cruz, Dario S. Zamboni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41009faa319b4c89b800738bd6213733
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spelling	oai:doaj.org-article:41009faa319b4c89b800738bd62137332021-12-02T15:36:00ZLeishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition10.1038/s41467-019-13356-22041-1723https://doaj.org/article/41009faa319b4c89b800738bd62137332019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13356-2https://doaj.org/toc/2041-1723NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which leads to autophagy-mediated NLRP3 degradation.Renan V. H. de CarvalhoDjalma S. Lima-JuniorMarcus Vinícius G. da SilvaMarisa DiluccaTamara S. RodriguesCatarina V. HortaAlexandre L. N. SilvaPatrick F. da SilvaFabiani G. FrantzLucas B. LorenzonMarcos Michel SouzaFausto AlmeidaLilian M. CantanhêdeRicardo de Godoi M. FerreiraAngela K. CruzDario S. ZamboniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Renan V. H. de Carvalho Djalma S. Lima-Junior Marcus Vinícius G. da Silva Marisa Dilucca Tamara S. Rodrigues Catarina V. Horta Alexandre L. N. Silva Patrick F. da Silva Fabiani G. Frantz Lucas B. Lorenzon Marcos Michel Souza Fausto Almeida Lilian M. Cantanhêde Ricardo de Godoi M. Ferreira Angela K. Cruz Dario S. Zamboni Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
description	NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which leads to autophagy-mediated NLRP3 degradation.
format	article
author	Renan V. H. de Carvalho Djalma S. Lima-Junior Marcus Vinícius G. da Silva Marisa Dilucca Tamara S. Rodrigues Catarina V. Horta Alexandre L. N. Silva Patrick F. da Silva Fabiani G. Frantz Lucas B. Lorenzon Marcos Michel Souza Fausto Almeida Lilian M. Cantanhêde Ricardo de Godoi M. Ferreira Angela K. Cruz Dario S. Zamboni
author_facet	Renan V. H. de Carvalho Djalma S. Lima-Junior Marcus Vinícius G. da Silva Marisa Dilucca Tamara S. Rodrigues Catarina V. Horta Alexandre L. N. Silva Patrick F. da Silva Fabiani G. Frantz Lucas B. Lorenzon Marcos Michel Souza Fausto Almeida Lilian M. Cantanhêde Ricardo de Godoi M. Ferreira Angela K. Cruz Dario S. Zamboni
author_sort	Renan V. H. de Carvalho
title	Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
title_short	Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
title_full	Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
title_fullStr	Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
title_full_unstemmed	Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
title_sort	leishmania rna virus exacerbates leishmaniasis by subverting innate immunity via tlr3-mediated nlrp3 inflammasome inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/41009faa319b4c89b800738bd6213733
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Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

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