Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

NLRP3 activation by Leishmania parasites is critical to the outcome of the disease. Here the authors show that LRV, a virus infecting Leishmania strains associated with more severe human disease, enables the parasite to suppress the inflammasome by activating type 1 interferon through TLR3, which le...

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Autores principales: Renan V. H. de Carvalho, Djalma S. Lima-Junior, Marcus Vinícius G. da Silva, Marisa Dilucca, Tamara S. Rodrigues, Catarina V. Horta, Alexandre L. N. Silva, Patrick F. da Silva, Fabiani G. Frantz, Lucas B. Lorenzon, Marcos Michel Souza, Fausto Almeida, Lilian M. Cantanhêde, Ricardo de Godoi M. Ferreira, Angela K. Cruz, Dario S. Zamboni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/41009faa319b4c89b800738bd6213733
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