Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering

Abstract Extracellular matrix (ECM) provides structural support for cell growth, attachments and proliferation, which greatly impact cell fate. Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alter...

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Autores principales:	Nurit Bar-Shai, Orna Sharabani-Yosef, Meiron Zollmann, Ayelet Lesman, Alexander Golberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4106eeafc7de4ae593cf1b1c3cf54467
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spelling	oai:doaj.org-article:4106eeafc7de4ae593cf1b1c3cf544672021-12-02T18:24:53ZSeaweed cellulose scaffolds derived from green macroalgae for tissue engineering10.1038/s41598-021-90903-22045-2322https://doaj.org/article/4106eeafc7de4ae593cf1b1c3cf544672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90903-2https://doaj.org/toc/2045-2322Abstract Extracellular matrix (ECM) provides structural support for cell growth, attachments and proliferation, which greatly impact cell fate. Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates. Decellularization–recellularization approach was used to fabricate seaweed cellulose-based scaffolds for in-vitro mammalian cell growth. Both scaffolds were confirmed nontoxic to fibroblasts, indicated by high viability for up to 40 days in culture. Each seaweed cellulose structure demonstrated distinct impact on cell behavior and proliferation rates. The Cladophora sp. scaffold promoted elongated cells spreading along its fibers’ axis, and a gradual linear cell growth, while the Ulva sp. porous surface, facilitated rapid cell growth in all directions, reaching saturation at week 3. As such, seaweed-cellulose is an environmentally, biocompatible novel biomaterial, with structural variations that hold a great potential for diverse biomedical applications, while promoting aquaculture and ecological agenda.Nurit Bar-ShaiOrna Sharabani-YosefMeiron ZollmannAyelet LesmanAlexander GolbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nurit Bar-Shai Orna Sharabani-Yosef Meiron Zollmann Ayelet Lesman Alexander Golberg Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
description	Abstract Extracellular matrix (ECM) provides structural support for cell growth, attachments and proliferation, which greatly impact cell fate. Marine macroalgae species Ulva sp. and Cladophora sp. were selected for their structural variations, porous and fibrous respectively, and evaluated as alternative ECM candidates. Decellularization–recellularization approach was used to fabricate seaweed cellulose-based scaffolds for in-vitro mammalian cell growth. Both scaffolds were confirmed nontoxic to fibroblasts, indicated by high viability for up to 40 days in culture. Each seaweed cellulose structure demonstrated distinct impact on cell behavior and proliferation rates. The Cladophora sp. scaffold promoted elongated cells spreading along its fibers’ axis, and a gradual linear cell growth, while the Ulva sp. porous surface, facilitated rapid cell growth in all directions, reaching saturation at week 3. As such, seaweed-cellulose is an environmentally, biocompatible novel biomaterial, with structural variations that hold a great potential for diverse biomedical applications, while promoting aquaculture and ecological agenda.
format	article
author	Nurit Bar-Shai Orna Sharabani-Yosef Meiron Zollmann Ayelet Lesman Alexander Golberg
author_facet	Nurit Bar-Shai Orna Sharabani-Yosef Meiron Zollmann Ayelet Lesman Alexander Golberg
author_sort	Nurit Bar-Shai
title	Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
title_short	Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
title_full	Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
title_fullStr	Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
title_full_unstemmed	Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
title_sort	seaweed cellulose scaffolds derived from green macroalgae for tissue engineering
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4106eeafc7de4ae593cf1b1c3cf54467
work_keys_str_mv	AT nuritbarshai seaweedcellulosescaffoldsderivedfromgreenmacroalgaefortissueengineering AT ornasharabaniyosef seaweedcellulosescaffoldsderivedfromgreenmacroalgaefortissueengineering AT meironzollmann seaweedcellulosescaffoldsderivedfromgreenmacroalgaefortissueengineering AT ayeletlesman seaweedcellulosescaffoldsderivedfromgreenmacroalgaefortissueengineering AT alexandergolberg seaweedcellulosescaffoldsderivedfromgreenmacroalgaefortissueengineering
_version_	1718378090375151616

Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering

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