EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling.

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Autores principales:	Sarah R. Needham, Selene K. Roberts, Anton Arkhipov, Venkatesh P. Mysore, Christopher J. Tynan, Laura C. Zanetti-Domingues, Eric T. Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J. Rolfe, David T. Clarke, Martyn D. Winn, Alireza Lajevardipour, Andrew H. A. Clayton, Linda J. Pike, Michela Perani, Peter J. Parker, Yibing Shan, David E. Shaw, Marisa L. Martin-Fernandez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
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spelling	oai:doaj.org-article:4106f1db16d64a39ab5d782e227f6e6e2021-12-02T16:57:02ZEGFR oligomerization organizes kinase-active dimers into competent signalling platforms10.1038/ncomms133072041-1723https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13307https://doaj.org/toc/2041-1723Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling.Sarah R. NeedhamSelene K. RobertsAnton ArkhipovVenkatesh P. MysoreChristopher J. TynanLaura C. Zanetti-DominguesEric T. KimValeria LosassoDimitrios KorovesisMichael HirschDaniel J. RolfeDavid T. ClarkeMartyn D. WinnAlireza LajevardipourAndrew H. A. ClaytonLinda J. PikeMichela PeraniPeter J. ParkerYibing ShanDavid E. ShawMarisa L. Martin-FernandezNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah R. Needham Selene K. Roberts Anton Arkhipov Venkatesh P. Mysore Christopher J. Tynan Laura C. Zanetti-Domingues Eric T. Kim Valeria Losasso Dimitrios Korovesis Michael Hirsch Daniel J. Rolfe David T. Clarke Martyn D. Winn Alireza Lajevardipour Andrew H. A. Clayton Linda J. Pike Michela Perani Peter J. Parker Yibing Shan David E. Shaw Marisa L. Martin-Fernandez EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
description	Epidermal growth factor receptors have been shown to oligomerise upon binding to their cognate ligands. Here, the authors use biochemical, biophysical and cell biology techniques to analyse the structures of these oligomers, and argue that these formations are required for signalling.
format	article
author	Sarah R. Needham Selene K. Roberts Anton Arkhipov Venkatesh P. Mysore Christopher J. Tynan Laura C. Zanetti-Domingues Eric T. Kim Valeria Losasso Dimitrios Korovesis Michael Hirsch Daniel J. Rolfe David T. Clarke Martyn D. Winn Alireza Lajevardipour Andrew H. A. Clayton Linda J. Pike Michela Perani Peter J. Parker Yibing Shan David E. Shaw Marisa L. Martin-Fernandez
author_facet	Sarah R. Needham Selene K. Roberts Anton Arkhipov Venkatesh P. Mysore Christopher J. Tynan Laura C. Zanetti-Domingues Eric T. Kim Valeria Losasso Dimitrios Korovesis Michael Hirsch Daniel J. Rolfe David T. Clarke Martyn D. Winn Alireza Lajevardipour Andrew H. A. Clayton Linda J. Pike Michela Perani Peter J. Parker Yibing Shan David E. Shaw Marisa L. Martin-Fernandez
author_sort	Sarah R. Needham
title	EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
title_short	EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
title_full	EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
title_fullStr	EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
title_full_unstemmed	EGFR oligomerization organizes kinase-active dimers into competent signalling platforms
title_sort	egfr oligomerization organizes kinase-active dimers into competent signalling platforms
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4106f1db16d64a39ab5d782e227f6e6e
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EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

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